Establishment of temperature control scheme for microbioreactor operation using integrated microheater

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• 作者：Muhd Nazrul Hisham Zainal Alam ; Amir Ali Amiri Moghadam…
• 刊名：Microsystem Technologies
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：21
• 期：2
• 页码：415-428
• 全文大小：2,198 KB
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• 刊物类别：Engineering
• 刊物主题：Electronics, Microelectronics and Instrumentation
  Nanotechnology
  Mechanical Engineering
  Operating Procedures and Materials Treatment
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1858

文摘

This paper presents design and fabrication of a microbioreactor platform, and implementation of two temperature control methods (i.e. on-off and PID) and their performance evaluation on the microbioreactor platform (working volume ~300?μL). The temperature of the microbioreactor content is controlled by using a subminiature heater placed underneath the microbioreactor and is measured with a miniature Pt 100 sensor. The microbioreactor is also integrated with a magnetic stirring capacity and a water evaporation control scheme. Programs for the two temperature control methods are written in LabVIEW software and implemented by interfacing them with a data acquisition card. It is shown that by implementing on–off and PID temperature control methods, the temperature of the microbioreactor content can be tightly controlled with an accuracy of approximately ±0.5?°C of the set point values. Both control methods also provide a good response and settling time values (i.e. around 2?min). Contrary to the on/off control method, the PID control method requires no adjustments whenever the set-point values are modified. The PID temperature control method works well for the entire tested range.