Gut microbiota disturbance during helminth infection: can it affect cognition and behaviour of children?
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- 作者：Vanina Guernier ; Bradley Brennan ; Laith Yakob…
- 关键词：Central nervous system ; Development ; Gut microbiota ; Helminths ; Mental health ; Microbiota ; gut ; brain axis
- 刊名：BMC Infectious Diseases
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：491KB
- 刊物主题：Infectious Diseases; Parasitology; Medical Microbiology; Tropical Medicine; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2334
- 卷排序：17
文摘
BackgroundBidirectional signalling between the brain and the gastrointestinal tract is regulated at neural, hormonal, and immunological levels. Recent studies have shown that helminth infections can alter the normal gut microbiota. Studies have also shown that the gut microbiota is instrumental in the normal development, maturation and function of the brain. The pathophysiological pathways by which helminth infections contribute to altered cognitive function remain poorly understood.