Duodenal-jejunal bypass changes the composition of the gut microbiota

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• 作者：Hideya Kashihara ; Mitsuo Shimada ; Kozo Yoshikawa ; Jun Higashijima…
• 关键词：Duodenal ; jejunal bypass ; Gut microbiota
• 刊名：Surgery Today
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：47
• 期：1
• 页码：137-140
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Surgery; Surgical Oncology;
• 出版者：Springer Japan
• ISSN：1436-2813
• 卷排序：47

文摘

This study investigated the composition of the gut microbiota in rats after duodenal-jejunal bypass (DJB) in comparison to that in rats injected with a glucagon-like peptide-1 (GLP-1) receptor analog. Six male 16-week-old OLETF rats were divided into three groups: a DJB group, a sham operation group, and a daily injection with a GLP-1 receptor agonist (liraglutide) group. The gut microbiota of the three groups was analyzed at postoperative week 8 using the PCR-clone library method targeting the 16S ribosomal RNA gene. The DJB group showed a decrease in Bacteroidia in comparison to the other two groups (DJB, 3.9 %/2.8 %; sham, 10.8 %/11.6 %; liraglutide, 33.2 %/14.1 %). In addition, DJB markedly increased the ratio of Gammaproteobacteria (DJB, 10.8 %/13.7 %; sham, 0.2 %/1.2 %; liraglutide, 0 %/0.1 %). DJB changes the composition of gut microbiota; these changes might be the factors that contribute to the effects of DJB.