The NMR study of human biological fluids for detection of pathologies NMR study of biological fluids

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• 作者：P. M. Beskaravainy (1)
  M. V. Molchanov (1)
  A. V. Suslikov (2)
  S. I. Paskevich (1)
  V. P. Kutyshenko (1)
  S. I. Vorob’ev (3)
  
• 关键词：biological fluids ; NMR ; biomarkers
• 刊名：Biochemistry (Moscow) Supplemental Series B: Biomedical Chemistry
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：8
• 期：2
• 页码：143-149
• 全文大小：
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• 作者单位：P. M. Beskaravainy (1)
  M. V. Molchanov (1)
  A. V. Suslikov (2)
  S. I. Paskevich (1)
  V. P. Kutyshenko (1)
  S. I. Vorob’ev (3)
  
  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences (ITEB RAS), Moscow region, Pushchino, ul. Institutskaya 3, 142290, Russia
  2. Federal Pushchino Hospital of the Research Center, Russian Academy of Sciences, Pushchino, Russia
  3. Sechenov First Moscow State Medical University, Moscow, 119991, Russia
  
• ISSN：1990-7516

文摘

The paper deals with the NMR spectra obtained using preparations of five different human biological body fluids. Characteristic metabolite signals of blood, urine, tears, saliva, and sweat spectra have been determined and classified. The biological body fluid samples were used for search and identification of biomarkers of cardiovascular disease. Absolute functional biomarkers for diseases such as coronary heart disease (CHD) have not been recognized even in the case acute myocardial infarction. A hypothesis explaining reasons of lack of such markers has been formulated. The results of comparative analysis of blood and urine samples from humans and some laboratory animals are given. Identify and analyze signals of metabolites of pathogenic microflora and their dynamics in the urine from patients with urogenital diseases have been determined and analyzed and characteristic biomarkers have been recognized.