“Microbiological aging-by Mechnikov. How to interpret these ideas today?

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• 作者：S. V. Stovbun (1)
  M. A. Gomberg (2)
  V. I. Sergienko (3)
  E. E. Bragina (4)
  V. A. Tverdislov (5)
  
• 关键词：microbiological aging ; electron microscopic study ; prostatitis ; skin aging changes
• 刊名：Biophysics
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：59
• 期：4
• 页码：651-652
• 全文大小：88 KB
• 参考文献：1. I. I. Mechnikov, / Studies in Optimism (Nauka, Moscow, 1988) [in Russian].
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  12. V. A. Tverdislov, A. E. Sidorova, and L. V. Yakovenko, / Biophysical Ecology (Krasand, Moscow, 2012) [in Russian].
  13. S. V. Stovbun, M. A. Gomberg, E. E. Bragina, and V. I. Sergienko, Byul. Eksperim. Biol. Med. 152(10), 478 (2011).
  14. M. Aumailley and T. Krieg, J. Invest. Dermatol. 106(2), 209 (1996). CrossRef
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  16. M. A. Gomberg, E. E. Bragina, Z. M. Getling, and S. V. Stovbun, Klin. Dermatol. Venerol. 10(2), 18 (2012).
  
• 作者单位：S. V. Stovbun (1)
  M. A. Gomberg (2)
  V. I. Sergienko (3)
  E. E. Bragina (4)
  V. A. Tverdislov (5)
  
  1. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, 119991, Russia
  2. Public Health Ministry of Russian Federation, Moscow State Medical Stomatological University, Moscow, 127473, Russia
  3. Research Institute of Physico-Chemical Medicine, Russian Federal Medical & Biological Agency, Moscow, 119435, Russia
  4. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119991, Russia
  5. Department of Physics, Moscow State University, Moscow, 119991, Russia
  
• ISSN：1555-6654

文摘

Mechnikov’s hypothesis that the key to prolongation of life lies in the introduction of useful microflora to the gut was not proved. Any microflora needs nutrition and perceives the human body only as a nutrient substrate. Destruction of the basement membranes, that delimit the epithelium contacting with aggressive microbiological environment from the deeper parts of the body, can lead to chronic inflammatory diseases and aging of the skin as a consequence of invasion of microorganisms. At the ultrastructural level this has been shown by the example of prostatitis and skin aging changes. Coupled with the penetration of germs, a flux of immune cells may cause autoimmune reactions due to abrupt changes in the molecular design during intermembrane transport. Thus, the physiological process of macroorganism aging can be viewed as a consequence of its microbiological destruction.