Susceptibility of Staphylococcus aureus bacteremia strains to different skin-derived antimicrobial proteins

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• 作者：Bente K?ten (1)
  Karsten Becker (2)
  Rainer Podschun (3)
  Christof von Eiff (2)
  Ulf Meyer-Hoffert (1) umeyerhoffert@dermatology.uni-kiel.de
  Jürgen Harder (1)
  Regine Gl?ser (1) rglaeser@dermatology.uni-kiel.de
• 关键词：Antimicrobial peptides – Innate immunity – Colonization – Bacterial flora – S. aureus
• 刊名：Archives of Dermatological Research
• 出版年：2012
• 出版时间：October 2012
• 年：2012
• 卷：304
• 期：8
• 页码：633-637
• 全文大小：235.7 KB
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• 作者单位：1. Department of Dermatology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany2. Institute of Medical Microbiology, University Hospital of Münster, Münster, Germany3. Institute for Infection Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
• ISSN：1432-069X

文摘

Staphylococcus aureus is a major human pathogen causing cutaneous infections to life-threatening bacteremia. These infections are often caused by strains derived from the own microflora suggesting that a disturbed epidermal barrier may promote invasion of S. aureus. Antimicrobial peptides and proteins (AMP) such as human beta-defensin-3 and RNase 7 contribute to control the colonization of S. aureus on the skin surface. This leads to the hypothesis that strains with a decreased susceptibility toward skin-derived AMP may better overcome the innate cutaneous defence barrier increasing the possibility of invading into the blood stream. To address this hypothesis we determined whether S. aureus strains from bacteremia patients are less susceptible to various skin-derived AMP than strains from healthy carriers. No differences in the AMP-killing activity against bacteremia-derived S. aureus and control strains were detected suggesting that the onset of S. aureus bacteremia is not based on the varying susceptibilities against skin-derived AMP.