CX₃C chemokine receptor 1 deficiency modulates microglia morphology but does not affect lesion size and short-term deficits after experimental stroke

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• 作者：Gerlinde van der Maten ; Vivien Henck ; Tadeusz Wieloch ; Karsten Ruscher
• 刊名：BMC Neuroscience
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：3117KB
• 刊物主题：Neurosciences; Neurobiology; Animal Models;
• 出版者：BioMed Central
• ISSN：1471-2202
• 卷排序：18

文摘

BackgroundThe fractalkine/CX₃C chemokine receptor 1 (CX₃CR1) pathway has been identified to play an essential role in the chemotaxis of microglia, leukocyte trafficking and microglia/macrophage recruitment. It has also been shown to be important in the regulation of the inflammatory response in the early phase after experimental stroke. The present study was performed to investigate if CX₃CR1 deficiency affects microglia during the first 14 days with consequences for tissue damage after experimental stroke.