Human epithelial-type ovarian tumour marker beta-2-microglobulin is regulated by the TGF-β signaling pathway
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- 作者：Wenwen Sun ; Lu Gui ; Xulei Zuo ; Lingyun Zhang…
- 关键词：B2M ; Epithelial ovarian cancer ; Tumorigenesis ; TGF ; β signaling ; Biomarker ; Therapeutic target
- 刊名：Journal of Translational Medicine
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：14
- 期：1
- 全文大小：2,271 KB
- 刊物主题：Biomedicine general; Medicine/Public Health, general;
- 出版者：BioMed Central
- ISSN：1479-5876
文摘
Background Beta-2-microglobulin (B2M), a light chain subunit of the major histocompatibility complex (MHC) class I complex, has been implicated in tumorigenesis. However, whether it is expressed in different epithelial-type ovarian tumours remains unknown. This study was performed to examine the expression of B2M in different histopathological types of ovarian tumours, to explore the function of B2M in ovarian cancer (OC) cells and to investigate the mechanisms underlying the regulation of B2M by the TGF-β signaling pathway.