Exercise training restores the cardiac microRNA-1 and ↿14 levels regulating Ca2+ handling after myocardial infarction
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- 作者：Stéphano Freitas Soares Melo ; Valério Garrone Barauna…
- 关键词：Exercise training ; Myocardial infarction ; MicroRNA ; Cardiac function
- 刊名：BMC Cardiovascular Disorders
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：1,076 KB
- 刊物主题：Cardiology; Cardiac Surgery; Angiology; Blood Transfusion Medicine; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2261
文摘
Background Impaired cardiomyocyte contractility and calcium handling are hallmarks of left ventricular contractile dysfunction. Exercise training has been used as a remarkable strategy in the treatment of heart disease. The microRNA-1, which targets sodium/calcium exchanger 1 (NCX), and microRNA-214, which targets sarcoplasmic reticulum calcium ATPase-2a (Serca2a), are involved in cardiac function regulation. Thus, the aim of this study was to evaluate the effect of exercise training on cardiac microRNA-1 and −214 expression after myocardial infarction.