Osteoporosis imaging: effects of bone preservation on MDCT-based trabecular bone microstructure parameters and finite element models
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- 作者：Thomas Baum ; Eduardo Grande Garcia ; Rainer Burgkart ; Olga Gordijenko…
- 关键词：Osteoporosis ; Bone preservation ; Trabecular bone microstructure ; Finite element model
- 刊名：BMC Medical Imaging
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：1,160 KB
- 刊物主题：Imaging / Radiology;
- 出版者：BioMed Central
- ISSN：1471-2342
文摘
Background Osteoporosis is defined as a skeletal disorder characterized by compromised bone strength due to a reduction of bone mass and deterioration of bone microstructure predisposing an individual to an increased risk of fracture. Trabecular bone microstructure analysis and finite element models (FEM) have shown to improve the prediction of bone strength beyond bone mineral density (BMD) measurements. These computational methods have been developed and validated in specimens preserved in formalin solution or by freezing. However, little is known about the effects of preservation on trabecular bone microstructure and FEM. The purpose of this observational study was to investigate the effects of preservation on trabecular bone microstructure and FEM in human vertebrae.