The effect of vascular peptide bioregulator on microcirculation in the brain cortex of old rats

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• 作者：I. B. Sokolova ; I. V. Sergeev ; G. A. Ryzhak ; V. Kh. Khavinson
• 关键词：vascular peptide bioregulator ; old animals ; density of microvascular network ; arterial reactivity ; brain
• 刊名：Advances in Gerontology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：6
• 期：4
• 页码：328-332
• 全文大小：
• 刊物主题：Geriatrics/Gerontology;
• 出版者：Pleiades Publishing
• ISSN：2079-0589
• 卷排序：6

文摘

At a video facility for the study of intravital brain microcirculation, we found that, after a course treatment with vascular peptide bioregulator, the microvasculature density of the pial tunic in old (22–24 months) rats increased by about 2.5–2.8 times; the constriction and dilative reactions of the pial arterioles increased after the application of noradrenaline and acetylcholine onto the brain surface, respectively. However, perfusion into brain tissues did not increase, but the degree of oxygen saturation in microvessels of this tissue region increased.