Adipose-derived endothelial and mesenchymal stem cells enhance vascular network formation on three-dimensional constructs in vitro

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• 作者：Alina Freiman ; Yulia Shandalov ; Dekel Rozenfeld ; Erez Shor…
• 关键词：Adipose MSCs ; Microvascular ECs ; Vascularization ; PLLA/PLGA scaffolds ; Tissue engineering
• 刊名：Stem Cell Research & Therapy
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：7
• 期：1
• 全文大小：2,342 KB
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• 作者单位：Alina Freiman (1) (2)
  Yulia Shandalov (2)
  Dekel Rozenfeld (2)
  Erez Shor (2)
  Sofia Segal (2)
  Dror Ben-David (3)
  Shai Meretzki (3)
  Dana Egozi (4)
  Shulamit Levenberg (2)
  
  1. Inter-departmental Program in Biotechnology, Technion-Israel Institute of Technology, Haifa, 32000, Israel
  2. Biomedical Engineering Department, Technion-Israel Institute of Technology, Haifa, 32000, Israel
  3. Bonus BioGroup Ltd., Haifa, 3508501, Israel
  4. Department of Plastic and Reconstructive Surgery, Kaplan Hospital, Rehovot, Israel
  
• 刊物主题：Stem Cells; Cell Biology;
• 出版者：BioMed Central
• ISSN：1757-6512

文摘

Background Adipose-derived mesenchymal stem cells (MSCs) have been gaining fame mainly due to their vast clinical potential, simple isolation methods and minimal donor site morbidity. Adipose-derived MSCs and microvascular endothelial cells have been shown to bear angiogenic and vasculogenic capabilities. We hypothesized that co-culture of human adipose-derived MSCs with human adipose-derived microvascular endothelial cells (HAMECs) will serve as an effective cell pair to induce angiogenesis and vessel-like network formation in three-dimensional scaffolds in vitro.