The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma
详细信息 查看全文
- 作者：Liangliang Xu ; Ming Zhang ; Xiaobo Zheng…
- 关键词：ciRS ; 7 ; microRNA ; 7 ; Microvascular invasion ; PIK3CD/Akt pathway ; Prognosis ; Hepatocellular carcinoma
- 刊名：Journal of Cancer Research and Clinical Oncology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：143
- 期：1
- 页码：17-27
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Oncology; Cancer Research; Internal Medicine; Hematology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-1335
- 卷排序：143
文摘
PurposeCircular RNAs (circRNA) represent a novel class of widespread and diverse endogenous RNAs that regulate gene expression in mammals. microRNA-7 (miR-7) is a well-demonstrated suppressor of hepatocellular carcinoma (HCC). Recent studies have showed that one such circRNA, ciRS-7 (also termed as Cdr1as) was the inhibitor and sponge of miR-7 in the embryonic zebrafish midbrain and islet cells. However, the relationships among ciRS-7, miR-7 and clinical features of HCC remain to be clarified.