Toward hemodynamic diagnosis of carotid artery stenosis based on ultrasound image data and computational modeling
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- 作者：Luísa C. Sousa (1)
Catarina F. Castro (1)
Carlos C. António (1)
André Miguel F. Santos (2)
Rosa Maria dos Santos (3)
Pedro Miguel A. C. Castro (3)
Elsa Azevedo (3)
Jo?o Manuel R. S. Tavares (2) - 关键词：Carotid artery bifurcation ; Image ; based analysis ; 3D reconstruction ; Computational hemodynamics ; Finite element method ; WSS descriptors
- 刊名：Medical and Biological Engineering and Computing
- 出版年：2014
- 出版时间：November 2014
- 年：2014
- 卷：52
- 期：11
- 页码：971-983
- 全文大小：5,064 KB
- 参考文献：1. AbuRahma AF, Srivastava M, Stone PA, Mousa AY, Jain A, Dean LS, Keiffer T, Emmett M (2011) Critical appraisal of the Carotid Duplex Consensus criteria in the diagnosis of carotid artery stenosis. J Vasc Surg 53(1):53-9 CrossRef
2. Almeida R, Feijóo R, Gale?o A, Padra C, Silva R (2000) Adaptive finite element computational fluid dynamics using an anisotropic error estimator. Comput Methods Appl Mech Eng 182(3-):379-00 CrossRef
3. Antiga L, Piccinelli M, Botti L, Ene-Iordache B, Remuzzi A, Steinman D (2008) An image-based modeling framework for patient-specific computational hemodynamics. Med Biol Eng Comput 46:1097-112 CrossRef
4. Botnar R, Rappitsch G, Scheidegger MB, Liepsch D, Perktold K, Boesiger P (2000) Hemodynamics in the carotid artery bifurcation: a comparison between numerical simulations and in vitro MRI measurements. J Biomech 33:137-44 CrossRef
5. Chan TF, Vese LA (2001) Active contours without edges. IEEE Trans Image Process 10(2):266-77 CrossRef
6. Davies PF (2009) Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology. Nat Clin Pract Cardiovascu Med 6(1):16-6 CrossRef
7. De Santis G, Mortier P, De Beule M, Segers P, Verdonck P, Verhegghe B (2010) Patient-specific computational fluid dynamics: structured mesh generation from coronary angiography. Med Biol Eng Comput 48(4):371-80 CrossRef
8. De Santis G, Conti M, Trachet B, De Schryver T, De Beule M, Degroote J, Vierendeels J, Auricchio F, Segers P, Verdonck P, Verhegghe B (2013) Haemodynamic impact of stent-vessel (mal) apposition following carotid artery stenting: mind the gaps! Comput Methods Biomech Biomed Engin 16(6):648-59 CrossRef
9. Dong J, Wong KK, Tu J (2013) Hemodynamics analysis of patient-specific carotid bifurcation: a CFD model of downstream peripheral vascular impedance. Int J Numer Method Biomed Eng 29(4):476-91 CrossRef
10. Fan Y, Jiang W, Zou Y, Li J, Chen J, Deng X (2009) Numerical simulation of pulsatile non-Newtonian flow in the carotid artery bifurcation. Acta Mech Sin 25(2):249-55 CrossRef
11. Filipovic N, Teng Z, Radovic M, Saveljic I, Fotiadis D, Parodi O (2013) Computer simulation of three-dimensional plaque formation and progression in the carotid artery. Med Biol Eng Comput 51(6):607-16 CrossRef
12. Gill JD, Ladak HM, Steinman DA, Fenster A (2000) Accuracy and variability assessment of a semiautomatic technique for segmentation of the carotid arteries from three dimensional ultrasound images. Med Phys 27:1333-342 CrossRef
13. Groen HC, Gijsen FJH, van der Lugt A, Ferguson MS, Hatsukami TS, van der Steen AFW, Yuan C, Wentzel JJ (2007) Plaque rupture in the carotid artery is localized at the high shear stress region: a case report. Stroke 38:2379-381 CrossRef
14. Hoi Y, Wasserman BA, Lakatta EG, Steinman DA (2010) Carotid bifurcation hemodynamics in older adults: effect of measured vs. assumed. J Biomech Eng 132(7):071006 CrossRef
15. Inzitari D, Eliasziw M, Gates P, Sharpe BL, Chan RK, Meldrum HE, Barnett HJ (2000) The causes and risk of stroke in patients with asymptomatic internal carotid artery stenosis. N Engl J Med 342:1693-701 Cross - 作者单位：Luísa C. Sousa (1)
Catarina F. Castro (1)
Carlos C. António (1)
André Miguel F. Santos (2)
Rosa Maria dos Santos (3)
Pedro Miguel A. C. Castro (3)
Elsa Azevedo (3)
Jo?o Manuel R. S. Tavares (2)
1. Faculdade de Engenharia, Instituto de Engenharia Mecanica (IDMEC-Polo FEUP), Universidade do Porto, Rua Dr. Roberto Frias, s/n, 4200-465, Porto, Portugal
2. Faculdade de Engenharia, Instituto de Engenharia Mecanica e Gest?o Industrial, Universidade do Porto, Rua Dr. Roberto Frias, s/n, 4200-465, Porto, Portugal
3. Departamento de Neurologia, Faculdade de Medicina, Hospital S?o Jo?o, Universidade do Porto, Alameda Professor Hernani Monteiro, 4200-319, Porto, Portugal - ISSN：1741-0444
文摘
The ability of using non-expensive ultrasound (US) image data together with computer fluid simulation to access various severities of carotid stenosis was inquired in this study. Subject-specific hemodynamic conditions were simulated using a developed finite element solver. Individual structured meshing of the common carotid artery (CCA) bifurcation was built from segmented longitudinal and cross-sectional US images; imposed boundary velocities were based on Doppler US measurements. Simulated hemodynamic parameters such as velocities, wall shear stress (WSS) and derived descriptors were able to predict disturbed flow conditions which play an important role in the development of local atherosclerotic plaques. Hemodynamic features from six individual CCA bifurcations were analyzed. High values of time-averaged WSS (TAWSS) were found at stenosis site. Low values of TAWSS were found at the bulb and at the carotid internal and external branches depending on the particular features of each patient. High oscillating shear index and relative residence time values assigned highly disturbed flows at the same artery surface regions that correlate only moderately with low TAWSS results. Based on clinic US examinations, results provide estimates of flow changes and forces at the carotid artery wall toward the link between hemodynamic behavior and stenosis pathophysiology.