The Speed of Increasing milk Feeds: a randomised controlled trial

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• 作者：Jane Abbott ; Janet Berrington ; Ursula Bowler ; Elaine Boyle ; Jon Dorling…
• 关键词：Preterm infants ; Milk feeds ; Milk volume ; Prematurity ; NEC ; Sepsis ; Parenteral nutrition ; Neurodevelopment ; RCT
• 刊名：BMC Pediatrics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：416KB
• 刊物主题：Pediatrics; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2431
• 卷排序：17

文摘

BackgroundIn the UK, 1–2% of infants are born very preterm (<32 weeks of gestation) or have very low birth weight (<1500 g). Very preterm infants are initially unable to be fed nutritional volumes of milk and therefore require intravenous nutrition. Milk feeding strategies influence several long and short term health outcomes including growth, survival, infection (associated with intravenous nutrition) and necrotising enterocolitis (NEC); with both infection and NEC being key predictive factors of long term disability. Currently there is no consistent strategy for feeding preterm infants across the UK. The SIFT trial will test two speeds of increasing milk feeds with the primary aim of determining effects on survival without moderate or severe neurodevelopmental disability at 24 months of age, corrected for prematurity. The trial will also examine many secondary outcomes including infection, NEC, time taken to reach full feeds and growth.