Differential changes and interactions of autonomic functioning and sleep architecture before and after 50 years of age

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• 作者：T. B. J. Kuo ; Jia-Yi Li ; Hsu-Ko Kuo ; Chang-Ming Chern ; C. C. H. Yang
• 关键词：Age ; Heart rate variability ; Miniature polysomnography ; Sleep quality ; 50 years old
• 刊名：AGE
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：38
• 期：1
• 全文大小：1,720 KB
• 参考文献：Ako M et al (2003) Correlation between electroencephalography and heart rate variability during sleep. Psychiatry Clin Neurosci 57:59–65. doi:10.​1046/​j.​1440-1819.​2003.​01080.​x PubMed CrossRef
  Bonnemeier H, Richardt G, Potratz J, Wiegand UK, Brandes A, Kluge N, Katus HA (2003) Circadian profile of cardiac autonomic nervous modulation in healthy subjects: differing effects of aging and gender on heart rate variability. J Cardiovasc Electrophysiol 14:791–799PubMed CrossRef
  Bonnet MH, Arand DL (1997) Heart rate variability: sleep stage, time of night, and arousal influences. Electroencephalogr Clin Neurophysiol 102:390–396PubMed CrossRef
  Bonnet MH, Arand DL (2007) EEG arousal norms by age. J Clin Sleep Med 3:271–274PubMed PubMedCentral
  Brandenberger G, Viola AU, Ehrhart J, Charloux A, Geny B, Piquard F, Simon C (2003) Age-related changes in cardiac autonomic control during sleep. J Sleep Res 12:173–180PubMed CrossRef
  Chen CY, Kuo TBJ, Hsieh IT, Yang CCH (2013) Electrical stimulation of the rostral ventrolateral medulla promotes wakefulness in rats. Sleep Med 14:1076–1084. doi:10.​1016/​j.​sleep.​2013.​06.​011 PubMed CrossRef
  Chung MH, Kuo TBJ, Hsu N, Chu H, Chou KR, Yang CCH (2009) Sleep and autonomic nervous system changes - enhanced cardiac sympathetic modulations during sleep in permanent night shift nurses. Scand J Work Environ Health 35:180–187PubMed CrossRef
  Crasset V, Mezzetti S, Antoine M, Linkowski P, Degaute JP, van de Borne P (2001) Effects of aging and cardiac denervation on heart rate variability during sleep. Circulation 103:84–88PubMed CrossRef
  Eaker ED, Chesebro JH, Sacks FM, Wenger NK, Whisnant JP, Winston M (1993) Cardiovascular disease in women. Circulation 88:1999–2009PubMed CrossRef
  Finley JP, Nugent ST (1995) Heart rate variability in infants, children and young adults. J Auton Nerv Syst 51:103–108PubMed CrossRef
  Frank SA, Roland DC, Sturis J, Byrne MM, Refetoff S, Polonsky KS, Van Cauter E (1995) Effects of aging on glucose regulation during wakefulness and sleep. Am J Physiol 269:e1006–1016PubMed
  Fu CH, Yang CCH, Lin CL, Kuo TBJ (2006) Effects of long-term vegetarian diets on cardiovascular autonomic functions in healthy postmenopausal women. Am J Cardiol 97:380–383. doi:10.​1016/​j.​amjcard.​2005.​08.​057 PubMed CrossRef
  Guzzetti S, Piccaluga E, Casati R, Cerutti S, Lombardi F, Pagani M, Malliani A (1988) Sympathetic predominance in essential hypertension: a study employing spectral analysis of heart rate variability. J Hypertens 6:711–717PubMed CrossRef
  Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) Circulation 93:1043–1065
  Kemp B, Varri A, Rosa AC, Nielsen KD, Gade J (1992) A simple format for exchange of digitized polygraphic recordings. Electroencephalogr Clin Neurophysiol 82:391–393PubMed CrossRef
  Kiyan E, Okumus G, Cuhadaroglu C, Deymeer F (2010) Sleep apnea in adult myotonic dystrophy patients who have no excessive daytime sleepiness. Sleep Breath = Schlaf Atmung 14:19–24. doi:10.​1007/​s11325-009-0270-6 PubMed CrossRef
  Kung YY, Yang CCH, Chiu JH, Kuo TBJ (2011) The relationship of subjective sleep quality and cardiac autonomic nervous system in postmenopausal women with insomnia under auricular acupressure. Menopause 18:638–645. doi:10.​1097/​gme.​0b013e31820159c1​ PubMed CrossRef
  Kuo TBJ, Chan SH (1993) Continuous, on-line, real-time spectral analysis of systemic arterial pressure signals. Am J Physiol 264:H2208–2213PubMed
  Kuo TBJ, Yang CCH (2005) Sleep-related changes in cardiovascular neural regulation in spontaneously hypertensive rats. Circulation 112:849–854. doi:10.​1161/​CIRCULATIONAHA.​104.​503920 PubMed CrossRef
  Kuo TBJ, Yien HW, Hseu SS, Yang CCH, Lin YY, Lee LC, Chan SH (1997) Diminished vasomotor component of systemic arterial pressure signals and baroreflex in brain death. Am J Physiol 273:H1291–1298PubMed
  Kuo TBJ, Lin T, Yang CCH, Li CL, Chen CF, Chou P (1999) Effect of aging on gender differences in neural control of heart rate. Am J Physiol 277:H2233–2239PubMed
  Kuo TBJ, Lai CJ, Shaw FZ, Lai CW, Yang CCH (2004) Sleep-related sympathovagal imbalance in SHR. Am J Physiol Heart Circ Physiol 286:H1170–1176. doi:10.​1152/​ajpheart.​00418.​2003 PubMed CrossRef
  Kuo TBJ, Shaw FZ, Lai CJ, Yang CCH (2008) Asymmetry in sympathetic and vagal activities during sleep-wake transitions. Sleep 31:311–320PubMed PubMedCentral
  Kuo TBJ, Chen CY, Hsu YC, Yang CCH (2012a) Performance of the frequency domain indices with respect to sleep staging. Clin Neurophysiol 123:1338–1345. doi:10.​1016/​j.​clinph.​2011.​11.​003 PubMed CrossRef
  Kuo TBJ, Chen CY, Lai CT, Chuan TY, Wu WY, Tsai SC, Yang CCH (2012b) Sleep disturbance among spontaneously hypertensive rats is mediated by an alpha1-adrenergic mechanism. Am J Hypertens 25:1110–1117. doi:10.​1038/​ajh.​2012.​93 PubMed CrossRef
  Kuo TBJ, Hong CH, Hsieh IT, Lee GS, Yang CCH (2014) Effects of cold exposure on autonomic changes during the last rapid eye movement sleep transition and morning blood pressure surge in humans. Sleep Med 15:986–997. doi:10.​1016/​j.​sleep.​2014.​03.​022 PubMed CrossRef
  Liao D, Barnes RW, Chambless LE, Simpson RJ Jr, Sorlie P, Heiss G (1995) Age, race, and sex differences in autonomic cardiac function measured by spectral analysis of heart rate variability—the ARIC study Atherosclerosis Risk in Communities. Am J Cardiol 76:906–912PubMed CrossRef
  Liu CC, Kuo TBJ, Yang CCH (2003) Effects of estrogen on gender-related autonomic differences in humans. Am J Physiol Heart Circ Physiol 285:H2188–2193PubMed CrossRef
  Loredo JS, Ziegler MG, Ancoli-Israel S, Clausen JL, Dimsdale JE (1999) Relationship of arousals from sleep to sympathetic nervous system activity and BP in obstructive sleep apnea. Chest 116:655–659PubMed CrossRef
  Lucini D, Mela GS, Malliani A, Pagani M (2002) Impairment in cardiac autonomic regulation preceding arterial hypertension in humans: insights from spectral analysis of beat-by-beat cardiovascular variability. Circulation 106:2673–2679PubMed CrossRef
  Lucini D, de Giacomi G, Tosi F, Malacarne M, Respizzi S, Pagani M (2013) Altered cardiovascular autonomic regulation in overweight children engaged in regular physical activity. Heart 99:376–381. doi:10.​1136/​heartjnl-2012-302616 PubMed CrossRef
  Melo RC et al (2005) Effects of age and physical activity on the autonomic control of heart rate in healthy men. Braz J Med Biol Res 38:1331–1338PubMed CrossRef
  Mitchell GF (2008) Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage J Appl Physiol (1985) 105:1652–1660 doi:10.1152/japplphysiol.90549.2008
  Moodithaya S, Avadhany ST (2012) Gender differences in age-related changes in cardiac autonomic nervous function. J Aging Res 2012:679345. doi:10.​1155/​2012/​679345 PubMed PubMedCentral CrossRef
  Mooradian AD, Korenman SG (2006) Management of the cardinal features of andropause. Am J Ther 13:145–160. doi:10.​1097/​01.​mjt.​0000132252.​80403.​c9 PubMed CrossRef
  Mozaffarian D et al (2015) Heart disease and stroke statistics—2015 update: a report from the American Heart Association. Circulation 131:e29–322. doi:10.​1161/​CIR.​0000000000000152​ PubMed CrossRef
  Nielsen T, Paquette T, Solomonova E, Lara-Carrasco J, Colombo R, Lanfranchi P (2010) Changes in cardiac variability after REM sleep deprivation in recurrent nightmares. Sleep 33:113–122PubMed PubMedCentral
  Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV (2004) Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 27:1255–1273PubMed
  Rao U, Poland RE, Lutchmansingh P, Ott GE, McCracken JT, Lin KM (1999) Relationship between ethnicity and sleep patterns in normal controls: implications for psychopathology and treatment. J Psychiatr Res 33:419–426PubMed CrossRef
  Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques, and scoring system for sleep stages of human subjects. U.S. Government Printing Office, Washington, DC
  Scholz UJ, Bianchi AM, Cerutti S, Kubicki S (1997) Vegetative background of sleep: spectral analysis of the heart rate variability. Physiol Behav 62:1037–1043PubMed CrossRef
  Sjoberg N, Brinkworth GD, Wycherley TP, Noakes M, Saint DA (2011) Moderate weight loss improves heart rate variability in overweight and obese adults with type 2 diabetes J Appl Physiol (1985) 110:1060–1064 doi:10.1152/japplphysiol.01329.2010
  Skrapari I, Tentolouris N, Perrea D, Bakoyiannis C, Papazafiropoulou A, Katsilambros N (2007) Baroreflex sensitivity in obesity: relationship with cardiac autonomic nervous system activity. Obesity (Silver Spring) 15:1685–1693. doi:10.​1038/​oby.​2007.​201 CrossRef
  Sowers MF et al (2008) Sex steroid hormone profiles are related to sleep measures from polysomnography and the Pittsburgh Sleep Quality Index. Sleep 31:1339–1349PubMed PubMedCentral
  Stein PK, Pu Y (2012) Heart rate variability, sleep and sleep disorders. Sleep Med Rev 16:47–66. doi:10.​1016/​j.​smrv.​2011.​02.​005 PubMed CrossRef
  Tsai HJ, Kuo TBJ, Lee GS, Yang CCH (2015) Efficacy of paced breathing for insomnia: enhances vagal activity and improves sleep quality. Psychophysiology 52:388–396. doi:10.​1111/​psyp.​12333 PubMed CrossRef
  Tuzcu EM et al (2001) High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: evidence from intravascular ultrasound. Circulation 103:2705–2710PubMed CrossRef
  Umetani K, Singer DH, McCraty R, Atkinson M (1998) Twenty-four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades. J Am Coll Cardiol 31:593–601PubMed CrossRef
  Van Cauter E, Leproult R, Plat L (2000) Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. Jama 284:861–868PubMed CrossRef
  Yang CCH, Kuo TBJ, Chan SH (1996) Auto- and cross-spectral analysis of cardiovascular fluctuations during pentobarbital anesthesia in the rat. Am J Physiol 270:H575–582PubMed
  Yang CCH, Lai CW, Lai HY, Kuo TBJ (2002) Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in humans. Neurosci Lett 329:213–216PubMed CrossRef
  Yang CCH, Shaw FZ, Lai CJ, Lai CW, Kuo TBJ (2003) Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in rats. Neurosci Lett 336:21–24PubMed CrossRef
  Yeragani VK, Sobolewski E, Kay J, Jampala VC, Igel G (1997) Effect of age on long-term heart rate variability. Cardiovasc Res 35:35–42PubMed CrossRef
  Young T, Peppard PE, Gottlieb DJ (2002) Epidemiology of obstructive sleep apnea: a population health perspective. Am J Res Crit Care Med 165:1217–1239CrossRef
  
• 作者单位：T. B. J. Kuo (1) (2) (3) (4) (5) (6) (9)
  Jia-Yi Li (1) (2) (7)
  Hsu-Ko Kuo (8)
  Chang-Ming Chern (1) (2) (4) (5) (9)
  C. C. H. Yang (1) (2) (3) (5)
  
  1. Institute of Brain Science, National Yang-Ming University, No. 155, Sec. 2, Li-Nong St., Taipei, 11221, Taiwan
  2. Sleep Research Center, National Yang-Ming University, No. 155, Sec. 2, Li-Nong St., Taipei, 11221, Taiwan
  3. Department of Education and Research, Taipei City Hospital, Taipei, Taiwan
  4. Division of Translational Medicine, Stroke & Neurovascular Center, Taipei Veterans General Hospital, Taipei, Taiwan
  5. Brain Research Center, National Yang-Ming University, Taipei, Taiwan
  6. Institute of Translational and Interdisciplinary Medicine, National Central University, Taoyuan, Taiwan
  9. Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan
  7. Department of Health and Leisure Management, Yuanpei University of Medical Technology, Hsinchu, Taiwan
  8. Department of Geriatrics and Gerontology and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Geriatrics and Gerontology
  Molecular Medicine
  
• 出版者：Springer Netherlands
• ISSN：1574-4647

文摘

We hypothesize that the time when age-related changes in autonomic functioning and in sleep structure occur are different and that autonomic functioning modulates sleep architecture differently before and after 50 years of age. Sixty-eight healthy subjects (aged 20 to 79 years old, 49 of them women) were enrolled. Correlation analysis revealed that wake after sleep onset, the absolute and relative value of stage 1 (S1; S1%), and relative value of stage 2 (S2) were positively correlated with age; however, sleep efficiency, stage 3 (S3), S3%, and rapid-eye-movement latency (REML) were negatively correlated with age. Significant degenerations of sleep during normal aging were occurred after 50 years of age; however, significant declines of autonomic activity were showed before 50 years of age. Before 50 years of age, vagal function during sleep was negatively correlated with arousal index; however, after 50 years of age, it was positively correlated with S1 and S1%. In addition, sympathetic activity during wake stage was positively related to S2% only after 50 years of age. Our results imply that the age-related changes in autonomic functioning decline promptly as individuals leave the younger part of their adult life span and that age-related changes in sleep slowly develop as individuals enter the older part of their adult life span. Furthermore, while various aspects of sleep architecture are modulated by both the sympathetic and vagal nervous systems during adult life span, the sleep quality is mainly correlated with the sympathetic division after 50 years of age. Keywords Age Heart rate variability Miniature polysomnography Sleep quality 50 years old