Association between glutathione S-transferase T1 null genotype and risk of myelodysplastic syndromes: a comprehensive meta-analysis

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• 作者：Minghao Fang (1)
  Wen Zeng (2)
  Lifang Huang (2)
  Shuang Qin (2)
  Jianfeng Zhou (2)
  Hanying Sun (2)
  Fankai Meng (2)
  
• 关键词：Glutathione S ; transferase ; Meta ; analysis ; Myelodysplastic syndromes
• 刊名：Tumor Biology
• 出版年：2013
• 出版时间：October 2013
• 年：2013
• 卷：34
• 期：5
• 页码：2747-2752
• 全文大小：
• 作者单位：Minghao Fang (1)
  Wen Zeng (2)
  Lifang Huang (2)
  Shuang Qin (2)
  Jianfeng Zhou (2)
  Hanying Sun (2)
  Fankai Meng (2)
  
  1. Department of Emergency Medicine, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
  2. Department of Hematology, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Jiefang Avenue, Wuhan, 430030, China
  
• ISSN：1423-0380

文摘

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematologic neoplasms, and the pathophysiology of these disorders is still unclear. Previous studies investigating the association between glutathione S-transferase Tl (GSTT1) null genotype and risk of MDS reported controversial results. We performed a comprehensive meta-analysis to clarify the effect of GSTT1 null genotype on risk of MDS. The strength of the association was measured by odds ratio (OR) with 95% confidence interval (CI). Fifteen studies were finally included, involving a total of 1,796 cases and 2,502 controls. Subgroup analysis was performed by race. Meta-analysis of all 15 studies showed that the GSTT1 null genotype was significantly associated with an increased risk of MDS (OR=1.47, 95% CI 1.16.88, P OR=0.002; I 2=54.4%). Besides, an obvious association was also observed after adjusting the heterogeneity (OR=1.32, 95% CI 1.13.54, P OR=0.001; I 2=9.0%). Subgroup analysis by race suggested that this association existed in both Caucasians (OR=1.40, 95% CI 1.04.89, P OR=0.027) and Asians (OR=1.68, 95% CI 1.00.81, P OR=0.049). This meta-analysis suggests the GSTT1 null genotype is significantly associated with an increased risk of MDS in both Caucasians and Asians.