MALDI-TOF-MS analysis of small molecules using modified mesoporous material SBA-15 as assisted matrix

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• 作者：Xiuhua Li (1) (2)
  Xue Wu (1)
  Ji Man Kim (3)
  Sung Soo Kim (3)
  Mingshi Jin (3)
  Donghao Li (1) (2)
  
• 刊名：Journal of The American Society for Mass Spectrometry
• 出版年：2009
• 出版时间：November 2009
• 年：2009
• 卷：20
• 期：11
• 页码：2167-2173
• 全文大小：640KB
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• 作者单位：Xiuhua Li (1) (2)
  Xue Wu (1)
  Ji Man Kim (3)
  Sung Soo Kim (3)
  Mingshi Jin (3)
  Donghao Li (1) (2)
  
  1. Key Laboratory of Nature Resource of Changbai Mountain and Functional Molecular (Yanbian University), Ministry of Education, Jilin, China
  2. Chemistry Department, Yanbian University, Park Road 977, Yanji City, Jilin Province, China
  3. Department of Chemistry, BK21 School of Chemical Materials Science, Department of Energy Science and SKKU Advanced Institute of Nanotechnology, Sungkyunkwan University, Suwon, Korea
  

文摘

Mesoporous silica, SBA-15 was successfully functionalized with quinoline moiety, and was applied as a matrix in the MALDI-TOF-MS analysis of small molecules. The modified SBA-15 material [SBA-15-8-(3-(triethoxysilyl)propoxy) quinoline, SBA-15-8QSi] was obtained by using calcined SBA-15 and 8-hydroxy quinoline. The structure of the functionalized mesoporous material was systemically characterized by TEM, the N2 adsorption-desorption isotherm technique and FT-IR spectra. Compared with DHB and SBA-15, SBA-15-8QSi demonstrated several advantages in the analysis of small molecules with MALDI-TOF-MS, such as less background interference ions, high homogeneity, and better reproducibility. Based on these results, the various analytical parameters were optimized. The ideal operating conditions were (1) methanol used as the dissolving solvent; (2) sample first dropping method; (3) a ratio between the analyte and the matrix of 3.5:10. Under these optimization conditions, a low detection limit (8 pmol for L-Arginine-HCl) and high reproducibility (?9%) were obtained. This technique was successfully applied to the analysis of various types of small molecules, such as saccharides, amino acids, metabolites, and natural honey.