Biallelic expression of Tssc4, Nap1l4, Phlda2 and Osbpl5 in adult cattle

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• 作者：MENGNAN WANG ; DONGJIE LI ; MINGYUE ZHANG ; WENZHI YANG ; GUOJIANG WU…
• 关键词：bovine ; Tssc4 ; Nap1l4 ; Phlda2 ; Osbpl5 ; allele ; specific expression ; imprinting
• 刊名：Journal of Genetics
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：94
• 期：3
• 页码：391-395
• 全文大小：1,073 KB
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• 作者单位：MENGNAN WANG (1)
  DONGJIE LI (2)
  MINGYUE ZHANG (1)
  WENZHI YANG (1)
  GUOJIANG WU (1)
  YALI CUI (1)
  SHIJIE LI (1)
  
  1. College of Life Science, Agricultural University of Hebei, Baoding, 071001, People’s Republic of China
  2. College of Life Science and Life Engineering, Science and Technology University of Hebei, Shijiazhuang, 050018, People’s Republic of China
  
• 刊物主题：Life Sciences, general; Microbial Genetics and Genomics; Plant Genetics & Genomics; Animal Genetics and Genomics; Evolutionary Biology;
• 出版者：Springer India
• ISSN：0973-7731

文摘

Genomic imprinting of the Cdkn1c/Kcnq1ot1 region shows lack of conservation between human and mouse. This region has been reported to be associated with Beckwith–Wiedemann syndrome (BWS) and cancer. To increase our understanding of imprinted genes in bovine Cdkn1c/Kcnq1ot1 imprinting cluster, we assessed the imprinting status of four cattle genes (Tssc4, Nap1l4, Phlda2 and Osbpl5) in seven types of tissues: heart, liver, spleen, lung, kidney, skeletal muscle and subcutaneous fat using polymorphism-based sequencing approach. It was found that all the four genes showed biallelic expression in tissues in which transcripts were detected. Nap1l4 and Tssc4 were detected in all examined tissues, while the expression of Phlda2 and Osbpl5 was tissue-specific. Phlda2 was not detected in heart and subcutaneous fat, and Osbpl5 was not detected in spleen and skeletal muscle. In addition, identification of species-specific imprinted genes is necessary to understand the evolution of genomic imprinting and to elucidate mechanisms leading to allele-specific expression. Keywords bovine Tssc4 Nap1l4 Phlda2 Osbpl5 allele-specific expression imprinting