Phytochemicals and biological studies of plants in genus Hedysarum
详细信息    查看全文
  • 作者：Yinmao Dong (4) (6)
    Dongyan Tang (4)
    Na Zhang (5)
    Yue Li (5)
    Chunhong Zhang (5)
    Li Li (6)
    Minhui Li (5)
  • 关键词：Hedysarum ; Chemical constituents ; Pharmacology ; Utilization ; TCM
  • 刊名：Chemistry Central Journal
  • 出版年：2013
  • 出版时间：December 2013
  • 年：2013
  • 卷：7
  • 期：1
  • 全文大小：268 KB
  • 参考文献：1. Chen DZ: Flora reipublicae popularis sinicae. / Beijing: Science Press 1999, 42:180.
    2. National Pharmacopoeia Committee: / Chinese PharmacopoeiaI. 2010, 142. [ / China Medical Science and Technology Press]
    3. Nechepurenko IV, Polovinka MP, Komarova NI, Korchagina DV, Salakhutdinov NF, Nechepurenko SB: Low-molecular-weight phenolic compounds from Hedysarum theinum roots. / Chem Nat Compd 2008, 44:31鈥?4. CrossRef
    4. Liu Y, Yang JS: Studies on chemical constituents isolated from Hedysarum polybotrys . / Chin Pharm J 2005, 40:1215鈥?216.
    5. Liu Y, Zhang QY, Zhao YY, Wang B, Hai LQ, Ying YP, Chen HB: Saponins from the roots of Hedysarum polybotrys . / Biochem Syst Ecol 2007, 35:389鈥?91. CrossRef
    6. Dang ZL, Liu XH, Zhao AN, Liang JD, Liang J, Liu ZH, Feng SL: Chemical structural features and primary molecular conformation of polysaccharide HPS4鈥?A from Hedysarum polybotrys. / Zhongcaoyao 2013, 44:141鈥?46.
    7. Wang W, Liang H, Wang B, Tu GZ, Chen HB, Zhao YY: A new natural product from the roots of Hedysarum multijugum . / J Peking University(Health Sciences) 2005, 37:532鈥?35.
    8. Chen SG: / Master鈥檚 thesis. Studies on the chemical constituents of Hedysarum scoparium and Inula Hupehensis: Lanzhou University; 2007.
    9. Neretina OV, Fedorov SV, Gromova AS, Lutskii VI, El鈥檏in YN: Flavonoids of Hedysarum setigerum . / Chem Nat Compd 2002, 38:194鈥?95. CrossRef
    10. Neretina OV, Gromova AS, Lutskii VI, Semenov AA, Ushakov IA, Makar鈥檈va TN, Owen NL: Secondary metabolites from Hedysarum setigerum . / Chem Nat Compd 2004, 40:91鈥?2. CrossRef
    11. Glyzina GS, Komissarenko NF: The flavonoids of Hedysarum gmelini . / Khim Prir Soedin 1967, 3:116.
    12. Glyzina GS, Bykov VI: Phenolic compounds of Hedysarum neglectum . / Khim Prir Soedin 1969, 5:272.
    13. Komissarenko AN, Nadezhina TP, Komissarenko NZ: Flavonoids and xanthones of Hedysarum connatum and H. alpinum . / Chem Nat Compd 1994, 30:521鈥?22. CrossRef
    14. Glyzin VI, Bykov VI, Glyzina GS: The phenolic compounds of Hedysarum komarovii . / Khim Prir Soedin 1968, 4:324.
    15. Glyzin VI, Ban鈥檏ovsii AI, Pavlova HS: Phenolic compounds of Hedysarum sachalinense and H. brandtii . / Khim Prir Soedin 1970, 6:372.
    16. Alaniya MD: Flavonoids of Hedysarum sericeum and H. caucasicum . / Plenum publishing corporation 1983, 19:612鈥?13.
    17. Hai LQ, Xu JJ, Kai Sai-er A, Zhang X, Ma LY: Chemical constituents of Hedysanun austrosibuicum b. Fedtsch. / Huaxi Yaoxue Zazhi 2006, 21:47鈥?8.
    18. Liu Y, Zhang Z, Zhang QY, Pu XP, Zhao YY: Study on chemical constituents and antioxidative activity of Radix Hedysari. / China Pharm 2010, 24:543鈥?49.
    19. Liu Y, Zhao YY, Chen HB, Wang B, Zhang QY: Chemical analysis of the principal flavonoids of Radix Hedysari by HPLC. / Nat Prod Commun 2010, 5:541鈥?44.
    20. Liu Y, Chen HB, Zhao YY, Wang B, Zhang QY, Zhang L, Tu PF: Quantification and stability studies on the flavonoids of Radix Hedysari. / J Agr Food Chem 2006, 54:6634鈥?639. CrossRef
    21. Hai LQ, Zhang QY, Liang H, Zhao YY, Du NS: Study on chemical constituents of Hedysarum polybotrys . / Acta Pharm Sinica 2003, 38:592鈥?95.
    22. Liu Y, Zhao YY, Tu GZ, Chen HB: Flavonoids of the roots of Hedysarum kirghisorum . / Biochem Syst Ecol 2005, 33:809鈥?12. CrossRef
    23. Liu Y, Chen HB, Tu GZ, Zhao YY: Studies on the constituents from the Hedysarum kirghisorum . / Medicinal Plant Research and Traditional Chinese Medicine Modernization-Fourth National Symposium on Medicinal Botany and Herbal Medicine 2004, 167鈥?69.
    24. Liu Y, Hai LQ, Zhao YY: Isoflavonoids from Hedysarum semenovii . / Chin Pharm J 2009, 44:1533鈥?535.
    25. Xu JJ, Hai LQ, Wang XQ, Chang JM, Zhang X: Chemical constituents of Hedysarum austrosibiricum b. / Fedtsch Huaxi Yaoxue Zazhi 2005, 20:214鈥?15.
    26. Nechepurenko IV, Polovinka NP, Sal鈥檔ikova OI, Pokrovskii LM, Komarova NI, Salakhutdinov NF, Nechepurenko SB: Components of the ethylacetate extract of Hedysarum theinum roots. / Chem Nat Compd 2007, 43:5鈥?. CrossRef
    27. Li YZ, Huang J, Guo HC, Ren B: Chemical constituents from Hedysarum polybotrys and their antitumor activities. / Chin Trad Herb Drugs 2009, 40:1195鈥?198.
    28. Wang W, Chen HB, Wang WM, Zhao YY: Studies on flavoniod constituents of Hedysarum multijugum . / Acta Pharm Sinica 2002, 37:196鈥?98.
    29. Wang W, Chen W, Chen HB, Liu JQ, Zhao YY: Study on chemical constituents of Hedysarum multijugum . / J Peking University (Health Sciences) 2001, 33:205鈥?08.
    30. Yang M, Wang W, Sun JH, Zhao YY, Liang H, Guo DA: Characterization of phenolic compounds in the crude extract of Hedysarum multijugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. / Rapid Commun Mass Spectrom 2007, 21:3833鈥?841. CrossRef
    31. Chen SG, Chen JJ, Gao K: Prenylisoflavone derivatives from the roots of Hedysarum scoparium . / Chem Pharm Bull 2007, 55:1181鈥?184. CrossRef
    32. Li YS, Chen JJ, Liao XR, Wang HY, Luo SD: Studies on chemical constituents of Hedysarum sikkimense var Rigidum. / Chin Trad Herb Drugs 2001, 32:489鈥?90.
    33. Nechepurenko IV, Komarova NI, Kuzovkina IN, Vdovitchenko MY, Polovinka MP, Salakhutdinov NF: Structure of oligomeric proanthocyanidines from Hedysarum thienum roots studied by thiolysis and MALDI-TOF MS. / Chem Nat Compd 2009, 45:420鈥?21. CrossRef
    34. Liu Y, Zhao YY, Chen HB, Zhang QY: Isolation and structural elucidation of an unstable isoflavonoid glycoside malonate from radix hedysari. / J Chin Pharm Sci 2010, 19:100鈥?03.
    35. Chen SG, Li Y, Zhao J, Gao K: Three new prenylfuranoisoflavonoids from the roots of Hedysarum scoparium . / Chin J Chem 2008, 26:531鈥?35. CrossRef
    36. Liu Y, Chen HB, Qiao L, Zhao YY: Two new isoprenyl chalcones from Hedysarum gmelinii . / J Asian Nat Prod Res 2005, 7:723鈥?27. CrossRef
    37. Rybachenko AI, Kvivut BA, Georgievkii VP: Fluorodensitometric determination of mangiferin and isomangiferin in Hedysarum flavescens and H. Alpinum. / Chem Nat Compd 1967, 12:395鈥?96. CrossRef
    38. Denisova OA, Glyzin VI, Rusakova SV, Pimenov MG: Xanthone C-glycosides of Hedysarum denticulatum . / Chem Nat Compd 1977, 13:245. CrossRef
    39. Glyzin VI, Ban鈥檏ovsii AI, Pimenov MG, Boryaev KI: Xanthone glycosides of Hedysarum flavescens . / Chem Nat Compd 1973, 9:409鈥?10. CrossRef
    40. Liu Y, Hai LQ, Zhao YY, Zhang QY: Studies on the chemical constituents of Hedysarum semenovii . / China Pharm 2008, 22:568鈥?69.
    41. Wang W, An DG, Chen HB, Tu GZ, Zhao YY: Two new pterocarpenes from Hedysarum multijugum . / J Asian Nat Prod Res 2003, 5:31鈥?4. CrossRef
    42. Miyase T, Fukushima S, Akiyama Y: Studies on the constituents of Hedysarum polybotrys Hand-Mazz. / Chem Pharm Bull 1984, 32:3267鈥?270. CrossRef
    43. Tian HY, Liu QG: A study on the chemical constituents of Hedysarum Taipeicum (Hand-Mazz) K T Fu. / J Southwest Nationalities Collge Nat Sci 1996, 22:182鈥?84.
    44. Liu Y, Ma XX, Chen HB, Tu GZ, He JM, Zhao YY: Chemical constituents of Hedysarum gmelinii . / J Chin Pharm Sci 2005, 14:75鈥?8.
    45. Hai LQ, Zhang QY, Wang Y, Zhao YY: Study on chemical constituents of Hedysarum polybotrys (IV). / Lishizhen Med Materia Medica Res 2006, 17:1659.
    46. Liu Y, Zhang QY, Chen HB, Wang B, An DG, Zhao YY: Structural determination of saponins from Hedysarum polybotrys . / Magn Reson Chem 2006, 44:1128鈥?130. CrossRef
    47. Wang W, Hai LQ, Zhao YY, Chen HB, Wang B, Liang H: Saponins from roots of Hedysarum multijugum . / China J Chin Mat Med 2007, 32:315鈥?17.
    48. Liu Y, Zhao YY, Chen HB, Wang B, Zhang QY: Structure elucidation and complete NMR spectral assignment of two triterpenoid saponins from Radix Hedysari. / Fitoterapia 2009, 80:127鈥?29. CrossRef
    49. Wang W, Zhao YY, Liang H, Jia Q, Chen HB: Coumestans from Hedysarum multijugum . / J Nat Prod 2006, 69:876鈥?80. CrossRef
    50. Neretina OV, Gromova AS, Lutskii VI, Semenov AA, Ushakov IA, Dmitrenok PS, Oven NL: Isolariciresinol glucoside, berberine, and phenolic acid from the aerial part of Hedysarum setigerum . / Chem Nat Compd 2004, 40:609鈥?10. CrossRef
    51. Hui HP, Feng SL, Zhao LG, Shi YK, Liu XH: Purification and structure identification of HPS. / LiShizhen Med Materia Medica Res 2010, 21:2302鈥?303.
    52. Wang W, Zhao YY, Wang B, Liang H, Tu GZ, Chen HB: Two new arylbenzofurans from the roots of Hedysarum multijugum . / J Asian Nat Prod Res 2007, 9:19鈥?2. CrossRef
    53. Zou K, Katsuko K, Zhu S: A novel compound from Hedysarum polybotrys . / J Asian Nat Prod Res 2007, 9:699鈥?03. CrossRef
    54. Cheng F, Zou K, Zhu S, Katsuko K: A new phenylpropionate derivative from the rhizomes of Hedysarum polybotrys . / Chi J Nat Med 2009, 7:351鈥?53. CrossRef
    55. Kukushkina TA, Vysochina GI, Karnaukhova NA, Selyutina IY: Content of mangiferin and total amount of xanthones in plants of some wild-growing and introduced Hedysarum (Fabaceae) species. / Rastitel鈥檔ye Resursy 2011, 47:99鈥?06.
    56. Ma D, Feng SL, Zhao LG, Liu XH, Li B, Li XD, Hu FD: Purification of the radix Hedysari polysaccharide and determination of its constitution. / Chin JAMP 2008, 25:177鈥?79.
    57. Hikino H, Funayama S, Endo K: Hypotensive principle of astragalus and Hedysarum roots. / Planta Med 1976, 30:297鈥?02. CrossRef
    58. Shi YK, Zhao LG, Liu XH, Hu FD, Cui F, Bi YY, Ma YF, Feng SL: Structural characterization of a sulfated glucan isolated from the aqueous extract of Hedysarum polybotrys Hand.-Mazz. / Carbohydr Polym 2012, 87:160鈥?69. CrossRef
    59. Tibe O, Meagher LP, Fraser K, Harding DRK: Condensed Tannins and Flavonoids from the Forage Legume Sulla (Hedysarum coronarium). / J Agr Food Chem 2011, 59:9402鈥?409. CrossRef
    60. Hui HP, Feng SL, Hu FD, Cui F, Wu YQ: Study on antioxidative activity of polysaccharide from Radix Hedysari in vitro . / J Anhui Agri Sci 2010, 38:4056鈥?057.
    61. Qiu T, Bai J, Jiang Y, Huang ZL: The effect of HPS on RNA and DNA content in several organs of mice. / Chin Trad Pat Med 1992, 14:33鈥?4.
    62. Zhang JP, Guo LP, Ruan SY: The effect of HPS on LPO and SOD content in SMC of rabbits. / J Gansu College of Trad Chin Med 1992, 9:3.
    63. Hai LQ, Kang JS, Sun L: Effects of aqueous extract of Hedysarum austrosibiricum on metabolism of oxyen free radicals in subacute aging mice caused by D-galactose. / China J Chin Materia Medica 2007, 32:729鈥?31.
    64. Mao XJ, Wang JZ, Wang FL: Effects of radix hedysari polysaccharide (RHPS) & astragali polysaccharide (APS) on immune functions. / Chin Pharm Bull 1989, 5:367鈥?72.
    65. Quan JX: The pharmacological research on Hedysari . / LiShizhen Med Materia Medica Res 1997, 8:178鈥?80.
    66. Wang W, You CG, Wang Y, Wang CM, Hu JC, Zheng HJ: The RHTS鈥?enhancement to the function of mouse immunocytes and its relation with CaM levels in the cells. / J Lanzhou University 2000, 5:112鈥?16.
    67. Yu L, Cao Y, Wei X, Xu L, Fang TH: The Immuno regulation effects of different extracts from radix Astragali and radix Hedysari. / J Anhui Agri Sci 2010, 38:20623鈥?0624.
    68. Wei DF, Zhang LF, Cheng WD, Gui MM, Li XY, Wei YX, Bao YC: Comparative study of Hedysari Radix and Astragali Radix alternative classic tonification prescriptions on humoral immunity in immunosuppressed mice. / Zhongyaocai 2012, 35:944鈥?48.
    69. Li SG, Wang DG, Tian W, Wang XX, Zhao JX, Liu Z, Chen R: Characterization and anti-tumor activity of a polysaccharide from Hedysarum polybotrys Hand.-Mazz. / Carbohydr Polym 2008, 73:344鈥?50. CrossRef
    70. Hu FD, Li XD, Zhao LG, Feng SL, Wang CM: Antidiabetic properties of purified polysaccharide from Hedysarum polybotrys . / Can J Physiol Pharm 2010, 88:64鈥?2. CrossRef
    71. Wei SY, Zhang PX, Han N, Dang Y, Zhang HB, Zhang DY, Fu ZG, Jiang BG: Effects of Hedysari polysaccharides on regeneration and function recovery following peripheral nerve injury in rats. / The American J Chin Med 2009, 37:57鈥?7. CrossRef
    72. Huang ZL, Cui ZM, Ren Y, Zhang J: Pharmacological effects on HPS complexes. / J Gansu College of Trad Chin Med 1987, 3:40鈥?3.
  • 作者单位：Yinmao Dong (4) (6)
    Dongyan Tang (4)
    Na Zhang (5)
    Yue Li (5)
    Chunhong Zhang (5)
    Li Li (6)
    Minhui Li (5)

    4. Department of chemistry, Harbin Institute of Technology, Harbin, 150000, China
    6. Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, 100048, China
    5. Baotou Medical College, No. 31 Construction Road, Baotou, Inner Mongolia, 014060, P. R. China
  • ISSN：1752-153X
文摘
In China, several species (Hedysarum polybotrys Hand.-Mazz., Hedysarum limprichtii Hlbr., Hedysarum vicioider Turcz. var. Taipeicum Hand.-Mazz. Liu, Hedysarum smithianum, et al.) of genus Hedysarum have a long history of use in traditional Chinese medicine (TCM). In TCM, these plants are used to increase the energy of the body. To date, 155 compounds, including flavonoids, triterpenes, coumarins, lignanoids, nitrogen compounds, sterols, carbohydrates, fatty compounds, and benzofuran, have been isolated from plants of the genus Hedysarum. Various chemical constituents contribute to the antioxidant, anti-tumor, anti-aging, anti-diabetic, and anti-hypertensive properties of these plants. Hedysarum species are used to treat infestation with gastrointestinal nematodes and may support the immune system and peripheral nervous system. In the present review, we summarize the research on the phytochemistry and pharmacology of Hedysarum species, which will be useful for better utilization of these important species in TCM.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址：北京市海淀区学院路29号 邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700