Trends of adverse drug reactions related-hospitalizations in Spain (2001-2006)

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• 作者：Pilar Carrasco-Garrido (1)
  López Ana de Andrés (1)
  Hernández Valentín Barrera (1)
  Gil ángel de Miguel (1)
  Rodrigo Jiménez-García (1)
  
• 关键词：ADR ; related hospitalizations ; Minimum Basic Data Set ; Costs.
• 刊名：BMC Health Services Research
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：10
• 期：1
• 全文大小：211KB
• 参考文献：1. Waller P: Pharmacoepidemiology-a tool for public health. / Pharmacoepidemiol Drug Saf 2001,10(2):165-2. CrossRef
  2. De Abajo F: Medications as a solution and a problem for public health. Brief overview of the pharmacoepidemiologic objectives. / Rev Esp Salud Publica 2001,75(4):281-.
  3. Kohn LT, Corrigan JM, Donaldson MS: / To Err is Human: Building a Safer Health System. Institute of Medicine: Washington DC; 2000.
  4. Van der Hooft CS, Sturkenboom MC, van Grootheest K, Kingma HJ, Stricker BH: Adverse drug reaction-related hospitalisations: a nationwide study in The Netherlands. / Drug Saf 2006,29(2):161-. CrossRef
  5. Kongkaew C, Noyce PR, Ashcroft DM: Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies. / Ann Pharmacother 2008,42(7):1017-5. CrossRef
  6. Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, Farrar K, Park BK, Breckenridge AM: Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. / BMJ 2004,329(7456):15-. CrossRef
  7. Van der Hooft CS, Dieleman JP, Siemes C, Aarnoudse AJ, Verhamme KM, Stricker BH, Sturkenboom MC: Adverse drug reaction-related hospitalisations: a population-based cohort study. / Pharmacoepidemiol Drug Saf 2008,17(4):365-1. CrossRef
  8. Trifirò G, Calogero G, Ippolito FM, Cosentino M, Giuliani R, Conforti A, Venegoni M, Mazzaglia G, Caputi AP: Adverse drug events in emergency department population: a prospective Italian study. / Pharmacoepidemiol Drug Saf 2005,14(5):333-0. CrossRef
  9. Queneau P, Bannwarth B, Carpentier F, Guliana JM, Bouget J, Trombert B, Leverve X, Lapostolle F, Borron SW, Adnet F: Association Pédagogique Nationale pour l'Enseignement de la Thérapeutique (APNET). Emergency department visits caused by adverse drug events: results of a French survey. / Drug Saf 2007,30(1):81-. CrossRef
  10. Onder G, Pedone C, Landi F, Cesari M, Della C, Bernabei R, Gambassi G: Adverse drug reactions as cause of hospital admissions: results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA). / Am Geriatr Soc 2002,50(12):1962-. CrossRef
  11. Bates DW, Spell N, Cullen DJ, Burdick E, Laird N, Petersen LA, Small SD, Sweitzer BJ, Leape LL: The costs of adverse drug events in hospitalized patients. In / Adverse Drug Events Prevention Study Group. / Volume 277. JAMA; 1997:307-1.
  12. Senst BL, Achusim LE, Genest RP, Cosentino LA, Ford CC, Little JA, Raybon SJ, Bates DW: Practical approach to determining costs and frequency of adverse drug events in a health care network. / Am J Health Syst Pharm 2001,58(12):1126-2.
  13. Rockett IR, Putnam SL, Jia H, Chang CF, Smith GS: Unmet substance abuse treatment need, health services utilization, and cost: a population-based emergency department study. / Ann Emerg Med 2005,45(2):118-7. CrossRef
  14. Instituto de Información sanitaria: Conjunto Mínimo Básico de Datos. Ministerio de Sanidad y Consumo. [http://www.msc.es/estadEstudios/estadisticas/cmbd.htm]
  15. [http://www.msps.es/ecieMaps-2010/basic_search/cie9mc_basic_search.html]
  16. Instituto de Información sanitaria: Conjunto Mínimo Básico de Datos. Ministerio de Sanidad y Consumo. [http://www.msc.es/estadEstudios/estadisticas/cmbd.htm]
  17. WHO: Collaborating center for international drug monitoring. / International monitoring of adverse reaction to drug:adverse reaction terminology 1980. DEM/NC/81.30; 31. XXI
  18. Brvar M, Fokter N, Bunc M, Mozina M: The frequency of adverse drug reaction related admissions according to method of detection, admission urgency and medical department specialty. / BMC Clin Pharmacol 2009.,9(8):
  19. Consumo de recursos según complejidad de los pacientes atendidos en los hospitales del Sistema Nacional de Salud [http://www.msc.es/estadEstudios/estadisticas/docs/GRD_2003.pdf]
  20. Navarro-Calderón E, Navarro MJ, Muelas J, Escoms V, Salazar A: Utilidad del CMBD en la declaración de efectos adversos a medicamentos. Boletín epidemiológico. / Centro Nacional de Epidemiología 2003,11(23):265-76.
  21. Alexopoulou A, Dourakis SP, Mantzoukis D, Pitsariotis T, Kandyli A, Deutsch M, Archimandritis AJ: Adverse drug reactions as a cause of hospital admissions: a 6-month experience in a single center in Greece. / Eur J Intern Med 2008,19(7):505-0. CrossRef
  22. Lazarou J, Pomeranz BH, Corey PN: Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. / JAMA 1998,279(15):1200-. 1200">CrossRef
  23. Beijer HJ, de Blaey CJ: Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies. / Pharm World Sci 2002,24(2):46-4. 121">CrossRef
  24. Zhang M, Holman CD, Preen DB, Brameld K: Repeat adverse drug reactions causing hospitalization in older Australians: a population-based longitudinal study 1980-003. / Br J Clin Pharmacol 2007,63(2):163-0. 125.2006.02839.x">CrossRef
  25. Samoy LJ, Zed PJ, Wilbur K, Balen RM, Abu-Laban RB, Roberts M: Drug-related hospitalizations in a tertiary care internal medicine service of a Canadian hospital: a prospective study. / Pharmacotherapy 2006,26(11):1578-6. CrossRef
  26. Howard RL, Avery AJ, Slavenburg S, Royal S, Pipe G, Lucassen P, Pirmohamed M: Which drugs cause preventable admissions to hospital? A systematic review. / Br J Clin Pharmacol 2007,63(2):136-7. 125.2006.02698.x">CrossRef
  27. Martín MT, Codina C, Tuset M, Carné X, Nogué S, Ribas J: Drug related problems as a cause of hospital admission. / Med Clin (Barc) 2002,118(6):205-0.
  28. Lema MC: / Economics, health and health care. / Volume 18. Neurologia; 2003:57-3.
  29. Librero J, Peiró S, Ordi?ana R: Chronic comorbility and homogeneity in diagnostic related groups. / Gac San 1999,13(4):292-02.
  30. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6963/10/287/prepub
  
• 作者单位：Pilar Carrasco-Garrido (1)
  López Ana de Andrés (1)
  Hernández Valentín Barrera (1)
  Gil ángel de Miguel (1)
  Rodrigo Jiménez-García (1)
  
  1. Department of Preventive Medicine and Public Health, Rey Juan Carlos University, Alcorcón, Madrid, Spain
  

文摘

Background Adverse drug reactions (ADR) are a substantial cause of hospital admissions. We conducted a nationwide study to estimate the burden of hospital admissions for ADRs in Spain during a six-year period (2001-2006) along with the associated total health cost. Methods Data were obtained from the national surveillance system for hospital data (Minimum Basic Data Set) maintained by the Ministry of Health and Consumer Affairs, and covering more than 95% of Spanish hospitals. From these admissions we selected all hospitalization that were code as drug-related (ICD-9-CM codes E), but intended forms of overdoses, errors in administration and therapeutics failure were excluded. The average number of hospitalizations per year, annual incidence of hospital admissions, average length of stay in the hospital, and case-fatality rate, were calculated. Results During the 2001-2006 periods, the total number of hospitalized patients with ADR diagnosis was 350,835 subjects, 1.69% of all acute hospital admissions in Spain. The estimated incidence of admissions due to ADR decreased during the period 2001-2006 (p < 0.05). More than five percent of patients (n = 19,734) died during an ADR-related hospitalization. The drugs most commonly associated with ADR-related hospitalization were antineoplastic and immunosuppressive drugs (n = 75,760), adrenal cortical steroids (n = 47,539), anticoagulants (n = 26,546) and antibiotics (n = 22,144). The costs generated by patients in our study increased by 19.05% between 2001 and 2006. Conclusions Approximately 1.69% of all acute hospital admissions were associated with ADRs. The rates were much higher for elderly patients. The total cost of ADR-related hospitalization to the Spanish health system is high and has increased between 2001 and 2006. ADRs are an important cause of admission, resulting in considerable use of national health system beds and a significant number of deaths.