Design of size-tunable molecularly imprinted polymer for selective adsorption of acetaminophen
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- 作者：Shih-hui Lee ; Ong Hui Lin ; Ruey-an Doong
- 关键词：Molecularly imprinting polymers (MIPs) ; Acetaminophen ; Adsorption ; Binding affinity ; Selectivity
- 刊名：Clean Technologies and Environmental Policy
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：19
- 期：1
- 页码：243-250
- 全文大小：
- 刊物类别：Engineering
- 刊物主题：Sustainable Development; Industrial Chemistry/Chemical Engineering; Industrial and Production Engineering; Environmental Engineering/Biotechnology; Environmental Economics;
- 出版者：Springer Berlin Heidelberg
- ISSN：1618-9558
- 卷排序：19
文摘
Pharmaceutical and personal care products are a broad and diverse group of biologically active compounds which are widely used and unregulated suspected carcinogens. In this study, the fabrication of molecularly imprinting polymer (MIP) particles by precipitation polymerisation were developed to selectively and rapidly capture acetaminophen, a commonly used analgesic and antipyretic drug, by hydrogen and hydrophobic bondings. Methacrylic acid, 3-(trimethoxysilyl) propyl methacrylate and 2, 2′-azobis-isobutyronitrile were utilised as the functional monomer, cross-linker and initiator. Acetonitrile was found to be the optimised porogen to obtain imprinted polymers with surface area and pore size of 447.2 m2/g and 3.35 nm. By adjusting the ratio of cross-linker and functional monomer, the particle size of MIPs changed from 177 to 2782 nm when the ratio increased from 0.43 to 12.8. In addition, the adsorption equilibrium of acetaminophen by MIPs can be reached within the first 30 min because of the surface imprinting characteristics and small particle sizes. In addition, the maximum adsorption capacity of acetaminophen and the adsorption constant, well fitted by Langmuir equation, were 0.35 mg/g and 0.045 L/mg. In addition, the MIPs exhibited the excellent selectivity to acetaminophen. The high surface area and adsorption capacity and excellent selectivity make MIPs an ideal tailor-made green material and can open the door to develop the novel technology for adsorption and removal of pharmaceutical and personal care products in the environment.