The versatility of the mitochondrial presequence processing machinery: cleavage, quality control and turnover

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• 作者：Daniel Poveda-Huertes ; Patrycja Mulica ; F. Nora Vögtle
• 关键词：Mitochondria ; Targeting signals ; Presequence proteases ; Quality control ; Peptide turnover
• 刊名：Cell and Tissue Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：367
• 期：1
• 页码：73-81
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Human Genetics; Proteomics; Molecular Medicine;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0878
• 卷排序：367

文摘

Mitochondria play a key role in several metabolic and cell biological pathways and have attracted increasing attention due to their implication in life-span, ageing and human diseases. Mitochondrial proteases have a special role in these multiple biological functions, as they are involved in the regulation of various processes, e.g., mitochondrial protein biogenesis and quality control, mitochondrial dynamics, mitophagy and programmed cell death. The mitochondrial presequence processing machinery serves the particular purpose of maturing the majority of incoming precursor proteins by presequence cleavage, to ensure a stable mature protein by trimming of intermediate N-termini and to remove free toxic targeting peptides.