DNA import into mitochondria
详细信息 查看全文
- 作者：Yu. M. Konstantinov ; A. Dietrich ; F. Weber-Lotfi ; N. Ibrahim…
- 关键词：Key wordsmitochondria ; DNA ; import ; mitochondrial permeability transition pore ; porin ; adenine nucleotide translocator ; plants ; yeasts ; mammals
- 刊名：Biochemistry (Moscow)
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：81
- 期：10
- 页码：1044-1056
- 全文大小：368 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Biochemistry
Bioorganic Chemistry
Microbiology
Biomedicine
Russian Library of Science - 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
- ISSN：1608-3040
- 卷排序：81
文摘
In recent decades, it has become evident that the condition for normal functioning of mitochondria in higher eukaryotes is the presence of membrane transport systems of macromolecules (proteins and nucleic acids). Natural competence of the mitochondria in plants, animals, and yeasts to actively uptake DNA may be directly related to horizontal gene transfer into these organelles occurring at much higher rate compared to the nuclear and chloroplast genomes. However, in contrast with import of proteins and tRNAs, little is known about the biological role and molecular mechanism underlying import of DNA into eukaryotic mitochondria. In this review, we discuss current state of investigations in this area, particularly specificity of DNA import into mitochondria and its features in plants, animals, and yeasts; a tentative mechanism of DNA import across the mitochondrial outer and inner membranes; experimental data evidencing several existing, but not yet fully understood mechanisms of DNA transfer into mitochondria. Currently available data regarding transport of informational macromolecules (DNA, RNA, and proteins) into the mitochondria do not rule out that the mechanism of protein and tRNA import as well as tRNA and DNA import into the mitochondria may partially overlap.