Evaluation of fluoride-labeled boronophenylalanine-PET imaging for the study of radiation effects in patients with glioblastomas

详细信息    查看全文

• 作者：Minoru Miyashita ; Shin-Ichi Miyatake ; Yoshio Imahori ; Kunio Yokoyama ; Shinji Kawabata ; Yoshinaga Kajimoto ; Masa-Aki Shibata ; Yoshinori Otsuki ; Mitsunori Kirihata and Koji Ono ; et al.
• 关键词：Boronophenylalanine ; Glioblastoma ; Positron emission tomography ; Radiation necrosis
• 刊名：Journal of Neuro-Oncology
• 出版年：2008
• 出版时间：September, 2008
• 年：2008
• 卷：89
• 期：2
• 页码：239-246
• 全文大小：299.6 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7373

文摘

Here we demonstrate that differentiation between glioblastoma (GB) tumor progression (TP) and radiation necrosis (RN) can be achieved with fluoride-labeled boronoalanine positron emission tomography (F-BPA-PET). F-BPA-PET images were obtained from histologically verified 38 GB, 8 complete RN, and 5 RN cases with partial residual tumors. The lesion/normal (L/N) ratios for these groups were 4.2 ± 1.4, 1.5 ± 0.3, and 2.0 ± 0.3, respectively. Ten GB patients underwent F-BPA-PET twice (once before and once after radiation treatment) due to enlargement of the original lesion or the development of new lesions post radiation. The L/N ratios of ten original site lesions had decreased by the second PET, and these lesions were revealed to be RN. In contrast, the L/N ratios of two lesions distant from the original site increased, and these lesions were revealed as cases of TP. Repeat PET imaging was found to be useful for evaluating changes in GB-associated tumor activity with respect to the treatment received.