Comparison of two dose levels of cyclophosphamide for successful stem cell mobilization in myeloma patients

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• 作者：Nils Winkelmann ; Max Desole…
• 关键词：Myeloma ; Cyclophosphamide ; Stem cell mobilization
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：142
• 期：12
• 页码：2603-2610
• 全文大小：405 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Internal Medicine
  Hematology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1335
• 卷排序：142

文摘

IntroductionEven in the era of proteasome inhibitors and immunomodulatory drugs, the autologous stem cell transplantation after high-dose melphalan continues to represent a standard approach for myeloma patients in first-line therapy. Different mobilization chemotherapies before stem cell apheresis have been published while cyclophosphamide at a dose level of up to 4 g/m2 has been evaluated and is commonly applied. In contrast, lower dose levels of cyclophosphamide (e.g., 1.5 g/m2) did not result in a sufficient collection of stem cells.