Development of natural and synthetic polymer-based semi-interpenetrating polymer network for controlled drug delivery: optimization and in vitro evaluation studies

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• 作者：Sahrish Rehmani ; Mahmood Ahmad ; Muhammad Usman Minhas ; Hina Anwar…
• 关键词：Pectin ; Polyvinyl alcohol ; 2 ; Acrylamido ; 2 ; methylpropane sulfonic acid ; Semi ; IPN hydrogel ; Controlled drug delivery ; Response surface methodology
• 刊名：Polymer Bulletin
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：74
• 期：3
• 页码：737-761
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Polymer Sciences; Soft and Granular Matter, Complex Fluids and Microfluidics; Characterization and Evaluation of Materials; Physical Chemistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1436-2449
• 卷排序：74

文摘

This research paper describes the development, optimization and in vitro characterization of chemically cross-linked pectin–polyvinyl alcohol-co-poly(2-Acrylamido-2-methylpropane sulfonic acid) semi-interpenetrating polymer network hydrogel [pectin–PVA-co-poly(AMPS) semi-IPN hydrogel] for controlled delivery of model drug tramadol HCl. Response surface methodology based on 32 factorial design was used for optimization and investigating the effect of independent factors: polymer-blend ratio (pectin:PVA = X₁) and monomer (AMPS = X₂) concentration on the dependent variables, swelling ratio (q_18th), percent drug release (R_18th, %), time required for 80 % drug release (t_{80 %}, h), drug encapsulation efficiency (DEE, %) and drug loaded contents (DLC, mg/g) in pectin-PVA-co-poly(AMPS) gels prepared by free radical polymerization. The optimized semi-IPN gel (FPP-10) showed controlled in vitro drug release (R_18th) of 56.34 % in 18 h, t_{80 %} of 30 h, and DEE of 23.40 %. These semi-IPN hydrogels were also characterized through SEM, FTIR, sol–gel analysis, swelling studies and drug release characteristics. Therefore, this newly synthesized polymeric network could be a potential polymeric system for controlled drug delivery of tramadol HCl for prolonged drug release.