ChARM: Discovery of combinatorial chromatin modification patterns in hepatitis B virus X-transformed mouse liver cancer using association rule mining
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- 作者：Sung Hee Park ; Sun-Min Lee ; Young-Joon Kim ; Sangsoo Kim
- 关键词：Combinatorial histone modifications ; Association rule mining ; Differential modifications ; Chromatin signature ; Hepatitis B virus X (HBx) ; transgenic mice ; Hepatocellular carcinoma
- 刊名：BMC Bioinformatics
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：17
- 期：16-supp
- 全文大小：2431KB
- 刊物主题：Bioinformatics; Microarrays; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Algorithms;
- 出版者：BioMed Central
- ISSN：1471-2105
- 卷排序：17
文摘
BackgroundVarious chromatin modifications, identified in large-scale epigenomic analyses, are associated with distinct phenotypes of different cells and disease phases. To improve our understanding of these variations, many computational methods have been developed to discover novel sites and cell-specific chromatin modifications. Despite the availability of existing methods, there is still room for further improvement when they are applied to resolve the histone code hypothesis. Hence, we aim to investigate the development of a computational method to provide new insights into de novo combinatorial pattern discovery of chromatin modifications to characterize epigenetic variations in distinct phenotypes of different cells.