Epigenetic modifying enzyme expression in asthmatic airway epithelial cells and fibroblasts
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- 作者：Dorota Stefanowicz ; Jari Ullah ; Kevin Lee ; Furquan Shaheen…
- 关键词：Asthma ; Histone modification ; Epigenetics ; Airway epithelium ; Airway epithelial cells ; Airway Fibroblasts ; Epigenome ; Histone code ; Post ; translational modification ; DNA methylation
- 刊名：BMC Pulmonary Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：1871KB
- 刊物主题：Pneumology/Respiratory System; Internal Medicine; Intensive / Critical Care Medicine;
- 出版者：BioMed Central
- ISSN：1471-2466
- 卷排序：17
文摘
BackgroundRecognition of the airway epithelium as a central mediator in the pathogenesis of asthma has necessitated greater understanding of the aberrant cellular mechanisms of the epithelium in asthma. The architecture of chromatin is integral to the regulation of gene expression and is determined by modifications to the surrounding histones and DNA. The acetylation, methylation, phosphorylation, and ubiquitination of histone tail residues has the potential to greatly alter the accessibility of DNA to the cells transcriptional machinery. DNA methylation can also interrupt binding of transcription factors and recruit chromatin remodelers resulting in general gene silencing. Although previous studies have found numerous irregularities in the expression of genes involved in asthma, the contribution of epigenetic regulation of these genes is less well known. We propose that the gene expression of epigenetic modifying enzymes is cell-specific and influenced by asthma status in tissues derived from the airways.