Epigenome-wide association study of DNA methylation in panic disorder

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• 作者：Mihoko Shimada-Sugimoto ; Takeshi Otowa ; Taku Miyagawa…
• 关键词：DNA methylation ; Panic disorder ; Epigenome ; wide association study ; Epigenetics ; Psychiatric disorder
• 刊名：Clinical Epigenetics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：9
• 期：1
• 全文大小：662KB
• 刊物主题：Human Genetics; Gene Function;
• 出版者：BioMed Central
• ISSN：1868-7083
• 卷排序：9

文摘

BackgroundPanic disorder (PD) is considered to be a multifactorial disorder emerging from interactions among multiple genetic and environmental factors. To date, although genetic studies reported several susceptibility genes with PD, few of them were replicated and the pathogenesis of PD remains to be clarified. Epigenetics is considered to play an important role in etiology of complex traits and diseases, and DNA methylation is one of the major forms of epigenetic modifications. In this study, we performed an epigenome-wide association study of PD using DNA methylation arrays so as to investigate the possibility that different levels of DNA methylation might be associated with PD.