In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain
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- 作者：Zac Chatterton ; Brigham J. Hartley ; Man-Ho Seok…
- 关键词：Brain ; DNA methylation ; Epigenetics ; Fetal ; Neuron ; Nicotine ; Neurodevelopment ; Prenatal ; Smoking ; Tobacco
- 刊名：Epigenetics & Chromatin
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：10
- 期：1
- 全文大小：2278KB
- 刊物主题：Animal Genetics and Genomics; Human Genetics; Plant Genetics & Genomics; Cell Biology; Gene Expression; Gene Function;
- 出版者：BioMed Central
- ISSN：1756-8935
- 卷排序：10
文摘
BackgroundIntrauterine exposure to maternal smoking is linked to impaired executive function and behavioral problems in the offspring. Maternal smoking is associated with reduced fetal brain growth and smaller volume of cortical gray matter in childhood, indicating that prenatal exposure to tobacco may impact cortical development and manifest as behavioral problems. Cellular development is mediated by changes in epigenetic modifications such as DNA methylation, which can be affected by exposure to tobacco.