Histone modifications in DNA damage response

详细信息    查看全文

• 作者：Lin-Lin Cao ; Changchun Shen ; Wei-Guo Zhu
• 关键词：DNA damage response ; histone modifications ; chromatin ; DNA repair
• 刊名：Science China Life Sciences
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：59
• 期：3
• 页码：257-270
• 全文大小：689 KB
• 刊物主题：Life Sciences, general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1869-1889

文摘

DNA damage is a relatively common event in eukaryotic cell and may lead to genetic mutation and even cancer. DNA damage induces cellular responses that enable the cell either to repair the damaged DNA or cope with the damage in an appropriate way. Histone proteins are also the fundamental building blocks of eukaryotic chromatin besides DNA, and many types of post-translational modifications often occur on tails of histones. Although the function of these modifications has remained elusive, there is ever-growing studies suggest that histone modifications play vital roles in several chromatin-based processes, such as DNA damage response. In this review, we will discuss the main histone modifications, and their functions in DNA damage response.