Epigenetic Control of Reprogramming and Transdifferentiation by Histone Modifications
详细信息 查看全文
- 作者：Hua Qin ; Andong Zhao ; Cuiping Zhang ; Xiaobing Fu
- 关键词：Somatic cells ; iPSCs ; Reprogramming ; Transdifferentiation ; Histone modifications ; Epigenetic ; Cell fate conversion
- 刊名：Stem Cell Reviews and Reports
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：12
- 期：6
- 页码：708-720
- 全文大小：1,155 KB
- 刊物主题：Cell Biology;
- 出版者：Springer US
- ISSN：1558-6804
- 卷排序：12
文摘
Somatic cells can be reprogrammed to pluripotent stem cells or transdifferentiate to another lineage cell type. Much efforts have been made to unravel the epigenetic mechanisms underlying the cell fate conversion. Histone modifications as the major epigenetic regulator are implicated in various aspects of reprogramming and transdifferentiation. Here, we discuss the roles of histone modifications on reprogramming and transdifferentiation and hopefully provide new insights into induction and promotion of the cell fate conversion by modulating histone modifications.