刊物主题:Animal Genetics and Genomics; Human Genetics; Plant Genetics & Genomics; Cell Biology; Gene Expression; Gene Function;
出版者:BioMed Central
ISSN:1756-8935
卷排序:10
文摘
BackgroundIn the mammalian zygote, epigenetic reprogramming is a tightly controlled process of coordinated alterations of histone and DNA modifications. The parental genomes of the zygote show distinct patterns of histone H3 variants and distinct patterns of DNA and histone modifications. The molecular mechanisms linking histone variant-specific modifications and DNA methylation reprogramming during the first cell cycle remain to be clarified.