Histone and DNA methylation control by H3 serine 10/threonine 11 phosphorylation in the mouse zygote

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• 作者：Jie Lan ; Konstantin Lepikhov ; Pascal Giehr ; Joern Walter
• 刊名：Epigenetics & Chromatin
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：10
• 期：1
• 全文大小：17724KB
• 刊物主题：Animal Genetics and Genomics; Human Genetics; Plant Genetics & Genomics; Cell Biology; Gene Expression; Gene Function;
• 出版者：BioMed Central
• ISSN：1756-8935
• 卷排序：10

文摘

BackgroundIn the mammalian zygote, epigenetic reprogramming is a tightly controlled process of coordinated alterations of histone and DNA modifications. The parental genomes of the zygote show distinct patterns of histone H3 variants and distinct patterns of DNA and histone modifications. The molecular mechanisms linking histone variant-specific modifications and DNA methylation reprogramming during the first cell cycle remain to be clarified.