Treatment of base of tongue cancer, stage III and stage IV with primary surgery: survival and functional outcomes

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• 作者：Khaled Al-Qahtani ; Jen Rieger…
• 关键词：Oropharynx ; Base of tongue ; Head and neck cancer ; Micro vascular reconstruction ; Speech ; Swallowing ; Local control and disease ; specific survival
• 刊名：European Archives of Oto-Rhino-Laryngology
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：272
• 期：8
• 页码：2027-2033
• 全文大小：403 KB
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• 作者单位：Khaled Al-Qahtani (1) (3) (5) (7)
  Jen Rieger (1) (2)
  Jeffery R. Harris (1) (3) (4)
  Alex Mlynarek (3)
  David Williams (4)
  Tahera Islam (6)
  Hadi Seikaly (1) (3) (4)
  
  1. Craniofacial Osseointegration and Maxillofacial Prosthetic Rehabilitation Unit (COMPRU), Misericordia Hospital, Caritas Health Group, Edmonton, AB, Canada
  3. Division of Otolaryngology-Head and Neck Surgery, University of Alberta, Edmonton, AB, Canada
  5. Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
  7. King Abdul Aziz University Hospital, King Saud University, P.O. BOX-245, Riyadh, 11411, Kingdom of Saudi Arabia
  2. Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada
  4. Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
  6. College of Medicine and Research Center, King Saud University, Riyadh, Kingdom of Saudi Arabia
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Otorhinolaryngology
  Neurosurgery
  Head and Neck Surgery
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1434-4726

文摘

This study examines functional outcome (speech and swallowing), survival, and disease control in patients receiving an intensified treatment regimen with primary aggressive surgery, and postoperative radiotherapy or postoperative concomitant chemoradiotherapy, for previously untreated, resectable, stage III and IV squamous cell carcinoma (SCC) of the tongue base. Sixty-six consecutive patients treated from June 1997 to June 2006 were followed prospectively through the Multidisciplinary Head and Neck Surgery Reconstruction Clinic. Speech and swallowing data were gathered at four evaluation times during the first year. Speech assessment was conducted by PERCI, Nasometer, and C-AIDS and swallowing assessment by Modified barium swallow, Diet survey and G-tube. Also, the overall survival, disease-specific survival and loco regional control were measured. The average age of the patients was 56.8, 85?% male and 15?% female. All patients had primary surgical resection and 83?% received postoperative radiotherapy and 17?% chemoradiation therapy. Overall survival at 3?years was 80.3?% and 5?years 52.2?%. Disease-specific survival at 3?years was 86.7?% and 5?years was 77.5?%. Local control was 94?%. Distal metastasis and second primary were found to be 7.5?% each. Primary surgical treatment of advanced BOT cancer offers excellent functional outcome, local control and disease-specific survival.