Distribution of Copper, Iron, and Zinc in Biological Samples (Scalp Hair, Serum, Blood, and Urine) of Pakistani Viral Hepatitis (A–E) Patients and Controls
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- 作者：Nida Fatima Kolachi (1)
Tasneem Gul Kazi (1)
Hassan Imran Afridi (1)
Naveed Kazi (1)
Ghulam Abbas Kandhro (1)
Abdul Qadir Shah (1)
Jameel Ahmed Baig (1)
Sham Kumar Wadhwa (1)
Sumaira Khan (1)
Faheem Shah (1)
Mohammad Khan Jamali (1)
Mohammad Balal Arain (1) - 关键词：Iron ; Copper ; Zinc ; Hepatitis (A–E) ; Gender ; Atomic absorption spectrophotometer
- 刊名：Biological Trace Element Research
- 出版年：2011
- 出版时间：October 2011
- 年：2011
- 卷：143
- 期：1
- 页码：116-130
- 全文大小：183KB
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Tasneem Gul Kazi (1)
Hassan Imran Afridi (1)
Naveed Kazi (1)
Ghulam Abbas Kandhro (1)
Abdul Qadir Shah (1)
Jameel Ahmed Baig (1)
Sham Kumar Wadhwa (1)
Sumaira Khan (1)
Faheem Shah (1)
Mohammad Khan Jamali (1)
Mohammad Balal Arain (1)
1. National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Sindh, Pakistan
文摘
The aim of the present study was to compare the level of copper (Cu), iron (Fe) and zinc (Zn) in biological samples (serum, blood, urine, and scalp hair) of patients suffering from different viral hepatitis (A, B, C, D, and E; n--21) of both gender age ranged 31-5?years. For comparative study, 255 age-matched control subjects, of both genders residing in the same city were selected as referents. The elements in the biological samples were analyzed by flame atomic absorption spectrophotometry, prior to microwave-assisted acid digestion. The validity and accuracy of the methodology was checked by using certified reference materials (CRMs) and with those values obtained by conventional wet acid digestion method on same CRMs. The results of this study showed that the mean values of Cu and Fe were higher in blood, sera, and scalp hair samples of hepatitis patients, while Zn level was found to be lower than age-matched control subjects. The urinary levels of these elements were found to be higher in the hepatitis patients than in the age-matched healthy controls (p-lt;-.05). These results are consistent with literature-reported data, confirming that the deficiency of zinc and hepatic iron and copper overload can directly cause lipid peroxidation and eventually hepatic damage.