Association of Environmental Toxic Elements in Biological Samples of Myocardial Infarction Patients at Different Stages
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  • 作者:Hassan Imran Afridi (1)
    Tasneem Gul Kazi (1)
    Naveed Kazi (2)
    Ghulam Abbas Kandhro (1)
    Jameel Ahmed Baig (1)
    Mohammad Khan Jamali (1)
    Mohammad Balal Arain (1)
    Abdul Qadir Shah (1)
    Faheem Shah (1)
    Sumaira Khan (1)
    Nida Fatima Kolachi (1)
  • 关键词:Toxic metals ; Myocardial infarction ; Biological samples ; Atomic absorption spectrophotometer
  • 刊名:Biological Trace Element Research
  • 出版年:2011
  • 出版时间:June 2011
  • 年:2011
  • 卷:141
  • 期:1-3
  • 页码:26-40
  • 全文大小:189KB
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  • 作者单位:Hassan Imran Afridi (1)
    Tasneem Gul Kazi (1)
    Naveed Kazi (2)
    Ghulam Abbas Kandhro (1)
    Jameel Ahmed Baig (1)
    Mohammad Khan Jamali (1)
    Mohammad Balal Arain (1)
    Abdul Qadir Shah (1)
    Faheem Shah (1)
    Sumaira Khan (1)
    Nida Fatima Kolachi (1)

    1. National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan
    2. Liaquat University of Medical and Health Sciences, Jamshoro, 76080, Pakistan
文摘
The exposure of toxic elements may directly or indirectly associate with different pathogenesis of heart diseases. In the present study, the association of arsenic (As), cadmium (Cd), cobalt (Co), lead (Pb), and nickel (Ni) in biological samples (whole blood and urine) and mortality from myocardial infarction (MI) patients at first, second, and third heart attacks was carried out. Both biological samples of 130 MI patients (77 male and 53 female), with ages ranging from 45 to 60?years, and 61 healthy persons (33 male and 28 female) of the same age group were collected. The elements in biological samples were assessed by electrothermal atomic absorption spectrophotometer, prior to microwave-assisted acid digestion. The validity of methodology was checked by the biological certified reference materials. During this study, 78% of 32 patients aged above 50?years, registered after third MI attack, died. In these subjects, the levels of As, Cd, Co, Ni, and Pb in blood samples were higher in MI patients as compared with referents (p-lt;-.05), while increased by 11.7%, 12.2%, 5.55%, and 7.2%, respectively, in the blood samples of those patients who tolerated the third MI attack (p--.12). The high level of understudied toxic elements may play a role in the mortality of MI patients.

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