Evaluation of inhibitory effect and apoptosis induction of Zyzyphus Jujube on tumor cell lines, an in?vitro preliminary study

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• 作者：Fatemeh Vahedi ; Mohsen Fathi Najafi and Kazem Bozari
• 关键词：Apoptosis ; Tumor cell line ; Zyzyphus Jujube
• 刊名：Cytotechnology
• 出版年：2008
• 出版时间：February, 2008
• 年：2008
• 卷：56
• 期：2
• 页码：105-111
• 全文大小：296.7 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Biotechnology
  Biomedicine
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-0778

文摘

In the present study, water extract of dried fruit of Zyzyphus Jujube was tested for its possible anticancer effect and induction of apoptosis on human tumor cell lines, HEp-2, HeLa and Jurkat cell lines. The inhibitory effect of water extract of this fruit on cell proliferation was assessed by MTT colorimetric assay. The induction of apoptosis of this extract was analyzed by DNA fragmentation analysis. Zyzyphus Jujube extract showed inhibitory effects on mentioned cell lines. Jurkat leukemic line was found the most sensitive cells with IC50 of 0.1 μg mL?1. Our study also showed a typical DNA laddering in this cell line. The present study showed cytotoxic activity of Zyzyphus Jujube on tumor cells. Although Zyzyphus Jujube has useful compounds for medical applications.