Strain variation in response to lung ischemia: role of MMP-12

详细信息    查看全文

• 作者：Clarke G Tankersley (1)
  Aigul Moldobaeva (2)
  Elizabeth M Wagner (1) (2) (3)
  
• 关键词：Angiogenesis ; Chemokines ; DBA/2J ; C57BL/6J ; Matrix metalloproteinases ; Neovascularization
• 刊名：Respiratory Research
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：13
• 期：1
• 全文大小：576KB
• 参考文献：1. Mitzner W, Lee W, Georgakopoulos D, Wagner E: Angiogenesis in the mouse lung. / Am J Pathol 2000,157(1):93-01. CrossRef
  2. Sánchez J, Moldobaeva A, McClintock J, Jenkins J, Wagner E: The role of CXCR2 in systemic neovascularization of the mouse lung. / J Appl Physiol 2007,103(2):594-99. CrossRef
  3. Srisuma S, Biswal SS, Mitzner WA, Gallagher SJ, Mai KH, Wagner EM: Identification of genes promoting angiogenesis in mouse lung by transcriptional profiling. / Am J Respir Cell Mol Biol 2003,29(2):172-79. CrossRef
  4. Arenberg DA, Polverini PJ, Kunkel SL, Shanafelt A, Hesselgesser J, Horuk R, Strieter RM: The role of CXC chemokines in the regulation of angiogenesis in non-small cell lung cancer. / J Leukoc Biol 1997,62(5):554-62.
  5. Belperio JA, Keane MP, Burdick MD, Londhe V, Xue YY, Li K, Phillips RJ, Strieter RM: Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury. / J Clin Invest 2002,110(11):1703-716.
  6. Strieter RM, Belperio JA, Keane MP: CXC chemokines in vascular remodeling related to pulmonary fibrosis. / Am J Respir Cell Mol Biol 2003,29(3 Suppl):S67-S69.
  7. Dean RA, Cox JH, Bellac CL, Doucet A, Starr AE, Overall CM: Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR-?CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. / Blood 2008,112(8):3455-464. CrossRef
  8. Van den Steen PE, Proost P, Wuyts A, Van Damme J, Opdenakker G: Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact. / Blood 2000,96(8):2673-681.
  9. Ebrahem Q, Chaurasia SS, Vasanji A, Qi JH, Klenotic PA, Cutler A, Asosingh K, Erzurum S, Anand-Apte B: Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo. / Am J Pathol 2010,176(1):496-03. CrossRef
  10. Cornelius LA, Nehring LC, Harding E, Bolanowski M, Welgus HG, Kobayashi DK, Pierce RA, Shapiro SD: Matrix metalloproteinases generate angiostatin: effects on neovascularization. / J Immunol 1998,161(12):6845-852.
  11. Raffetto JD, Khalil RA: Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. / Biochem Pharmacol 2008,75(2):346-59. CrossRef
  12. Kessenbrock K, Plaks V, Werb Z: Matrix metalloproteinases: regulators of the tumor microenvironment. / Cell 2010,141(1):52-7. CrossRef
  13. Heissig B, Nishida C, Tashiro Y, Sato Y, Ishihara M, Ohki M, Gritli I, Rosenkvist J, Hattori K: Role of neutrophil-derived matrix metalloproteinase-9 in tissue regeneration. / Histol Histopathol 2010,25(6):765-70.
  14. Adair-Kirk TL, Senior RM: Fragments of extracellular matrix as mediators of inflammation. / Int J Biochem Cell Biol 2008,40(6-):1101-110. CrossRef
  15. Arroyo AG, Iruela-Arispe ML: Extracellular matrix, inflammation, and the angiogenic response. / Cardiovasc Res 2010,86(2):226-35. CrossRef
  16. Huang K, Mitzner W, Rabold R, Schofield B, Lee H, Biswal S, Tankersley CG: Variation in senescent-dependent lung changes in inbred mouse strains. / J Appl Physiol 2007,102(4):1632-639. CrossRef
  17. Misra V, Lee H, Singh A, Huang K, Thimmulappa RK, Mitzner W, Biswal S, Tankersley CG: Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes. / Physiol Genomics 2007,31(3):429-40. CrossRef
  18. Cho HY, Kleeberger SR: Genetic mechanisms of susceptibility to oxidative lung injury in mice. / Free Radic Biol Med 2007,42(4):433-45. CrossRef
  19. Wesselkamper SC, Prows DR, Biswas P, Willeke K, Bingham E, Leikauf GD: Genetic susceptibility to irritant-induced acute lung injury in mice. / Am J Physiol Lung Cell Mol Physiol 2000,279(3):L575-L582.
  20. Chung MP, Monick MM, Hamzeh NY, Butler NS, Powers LS, Hunninghake GW: Role of repeated lung injury and genetic background in bleomycin-induced fibrosis. / Am J Respir Cell Mol Biol 2003,29(3 Pt 1):375-80. CrossRef
  21. Bartalesi B, Cavarra E, Fineschi S, Lucattelli M, Lunghi B, Martorana PA, Lungarella G: Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants. / Eur Respir J 2005,25(1):15-2. CrossRef
  22. Moldobaeva A, van Rooijen N, Wagner E: Effects of ischemia on lung macrophages. / PLoS One http://www.plosone.org/article/info%3Adoi%2F10.1371%1372Fjournal.pone.0026716.
  23. Eldridge L, Moldobaeva A, Wagner EM: Increased lung hyaluronan fragmentation during pulmonary ischemia. / Am J Physiol Lung Cell Mol Physiol 2011,301(5):L782-L788. CrossRef
  24. Wagner EM, Petrache I, Schofield B, Mitzner W: Pulmonary ischemia induces lung remodeling and angiogenesis. / J Appl Physiol 2006,100(2):587-93. CrossRef
  25. Wagner EM, Karagulova G, Jenkins J, Bishai J, McClintock J: Changes in lung permeability after chronic pulmonary artery obstruction. / J Appl Physiol 2006,100(4):1224-229. CrossRef
  26. Wagner EM, Sanchez J, McClintock JY, Jenkins J, Moldobaeva A: Inflammation and ischemia-induced lung angiogenesis. / Am J Physiol Lung Cell Mol Physiol 2008,294(2):L351-L357. CrossRef
  27. Loffek S, Schilling O, Franzke CW: Series “matrix metalloproteinases in lung health and disease- Biological role of matrix metalloproteinases: a critical balance. / The European respiratory journal: official journal of the European Society for Clinical Respiratory Physiology 2011,38(1):191-08. CrossRef
  28. Virchow V: Uber die Standpunkte in den Wissenschaftlichen Medizin. / Virchow Archiv 1847, 1:1-9.
  29. Michel RP, Hakim TS: Increased resistance in postobstructive pulmonary vasculopathy: structure-function relationships. / J Appl Physiol 1991,71(2):601-10.
  30. Charan NB, Carvalho P: Angiogenesis in bronchial circulatory system after unilateral pulmonary artery obstruction. / J Appl Physiol 1997,82(1):284-91.
  31. Weibel ER: Early stages in the development of collateral circulation to the lung in the rat. / Circ Res 1960, 8:353-76. CrossRef
  32. Remy-Jardin M, Duhamel A, Deken V, Bouaziz N, Dumont P, Remy J: Systemic Collateral Supply in Patients with Chronic Thromboembolic and Primary Pulmonary Hypertension: Assessment with Multi-Detector Row Helical CT Angiography. / Radiology 2005,235(1):274-81. CrossRef
  33. D’Alessio S, Fibbi G, Cinelli M, Guiducci S, Del Rosso A, Margheri F, Serrati S, Pucci M, Kahaleh B, Fan P, / et al.: Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis. / Arthritis Rheum 2004,50(10):3275-285. CrossRef
  34. Cheng P, Jiang FH, Zhao LM, Dai Q, Yang WY, Zhu LM, Wang BJ, Xu C, Bao YJ, Zhang YJ: Human macrophage metalloelastase correlates with angiogenesis and prognosis of gastric carcinoma. / Dig Dis Sci 2010,55(11):3138-146. CrossRef
  35. Mokres LM, Parai K, Hilgendorff A, Ertsey R, Alvira CM, Rabinovitch M, Bland RD: Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice. / American journal of physiology Lung cellular and molecular physiology 2010,298(1):L23-L35. CrossRef
  36. Zacchigna S, Zentilin L, Morini M, Dell’Eva R, Noonan DM, Albini A, Giacca M: AAV-mediated gene transfer of tissue inhibitor of metalloproteinases-1 inhibits vascular tumor growth and angiogenesis in vivo. / Cancer Gene Ther 2004,11(1):73-0. CrossRef
  37. Reed MJ, Koike T, Sadoun E, Sage EH, Puolakkainen P: Inhibition of TIMP1 enhances angiogenesis in vivo and cell migration in vitro. / Microvasc Res 2003,65(1):9-7. CrossRef
  38. De Paepe ME, Greco D, Mao Q: Angiogenesis-related gene expression profiling in ventilated preterm human lungs. / Exp Lung Res 2010,36(7):399-10. CrossRef
  
• 作者单位：Clarke G Tankersley (1)
  Aigul Moldobaeva (2)
  Elizabeth M Wagner (1) (2) (3)
  
  1. Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA
  2. Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, USA
  3. Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD, 21224, USA
  

文摘

Background Systemic neovascularization of the lung during chronic ischemia has been observed in all mammals studied. However, the proteins that orchestrate the complex interaction of new vessel growth and tunneling through lung tissue matrix have not been described. Although previous work has demonstrated the CXC chemokines are essential growth factors in the process of angiogenesis in mice and rats, key matrix proteins have not been identified. Methods Since the degradation of chemokines has been shown to be dependent on metalloproteinases (MMP), we first surveyed gene expression patterns (real time RT-PCR) of several lung matrix proteins in DBA/J (D2) mice and C57Bl/6 (B6) mice, strains known to have divergent parenchymal responses in other lung disease models. We studied changes in the time course of MMP-12 activity in D2 and B6 mice. Functional angiogenesis was determined 14 days after the onset of complete left lung ischemia induced by left pulmonary artery ligation (LPAL), using fluorescent microspheres. Results Our results confirmed higher levels of MMP-12 gene expression in D2 mice relative to B6, which corresponded to a phenotype of minimal systemic angiogenesis in D2 mice and more robust angiogenesis in B6 mice (p-lt;-.01). MMP-12 activity decreased over the course of 14 days in B6 mice whereas it increased in D2 mice (p-lt;-.05). MMP-12 was associated largely with cells expressing the macrophage marker F4/80. Genetic deficiency of MMP-12 resulted in significantly enhanced neovascularization (p-lt;-.01 from B6). Conclusion Taken together, our results suggest macrophage-derived MMP-12 contributes to angiostasis in the ischemic lung.