The cell cycle: a new entry in the field of Ca2+ signaling

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• 作者：L. Santella ; E. Ercolano and G. A. Nusco
• 关键词：Calcium signaling ; mitosis ; meiosis ; cyclin ; dependent kinase ; maturation ; promoting factor ; InsP3 fertilization
• 刊名：Cellular and Molecular Life Sciences (CMLS)
• 出版年：2005
• 出版时间：November, 2005
• 年：2005
• 卷：62
• 期：21
• 页码：2405-2413
• 全文大小：196 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Biomedicine
  Life Sciences
  Biochemistry
  
• 出版者：Birkh盲user Basel
• ISSN：1420-9071

文摘

Ca2+ signaling plays a crucial role in virtually all cellular processes, from the origin of new life at fertilization to the end of life when cells die. Both the influx of external Ca2+ through Ca2+-permeable channels and its release from intracellular stores are essential to the signaling function. Intracellular Ca2+ is influenced by mitogenic factors which control the entry and progression of the cell cycle; this is a strong indication for a role of Ca2+ in the control of the cycle, but surprisingly, the possibility of such a role has only been paid scant attention in the literature. Substantial progress has nevertheless been made in recent years in relating Ca2+ and the principal decoder of its information, calmodulin, to the modulation of various cycle steps. The aim of this review is to critically discuss the evidence for a role of Ca2+ in the cell cycle and to discuss Ca2+-dependent pathways regulating cell growth and differentiation.