Suspected inflammatory cardiomyopathy

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• 作者：K. Karatolios MD ; B. Maisch ; S. Pankuweit
• 关键词：Lyme borreliosis ; Borrelia burgdorferi ; Dilated cardiomyopathy ; Molecular biology ; Polymerase chain reaction ; Lyme ; Borreliose ; Borrelia burgdorferi ; Dilatative Kardiomyopathie ; Molekularbiologie ; Polymerasekettenreaktion
• 刊名：Herz
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：40
• 期：1-supp
• 页码：91-95
• 全文大小：326 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  
• 出版者：Urban & Vogel
• ISSN：1615-6692

文摘

Background Cardiac involvement in Lyme disease, caused by the tick-borne spirochete Borrelia burgdorferi, has been reported to occur in 0.3-- of infected patients in Europe. Cardiac manifestations may include conduction disturbances, and also myocarditis, pericarditis, and left ventricular dysfunction. We investigated the prevalence of B. burgdorferi DNA in endomyocardial biopsies from patients with suspected inflammatory heart disease and positive serology for B. burgdorferi. Methods and results In 64 patients, endomyocardial biopsies were taken after exclusion of coronary heart disease by coronary angiography, and investigated with polymerase chain reaction (PCR) for the presence of B. burgdorferi and cardiotropic viruses. B. burgdorferi DNA was not detected in any of the endomyocardial biopsies. Viruses, particularly parvovirus B19, were detected as infectious agents in 19 (30-) patients. Conclusion The results of our study demonstrate that PCR analysis of endomyocardial biopsies from patients with suspected inflammatory heart disease, including individuals with dilated cardiomyopathy (DCM) and positive serology for B. burgdorferi, did not reveal the B. burgdorferi genome in any biopsy sample.