Glandul?res Papillom des rechten Hauptbronchus

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• 作者：PD Dr. med. J. Wohlschl?ger (1)
  S. Welter MD (2)
  G. Stamatis MD (2)
  D. Theegarten MD (1)
  T. Hager MD (1)
  F. Mairinger MD (1)
  K. Worm MD (1)
  K.W. Schmid MD (1)
  K.M. Müller MD (3)
  
• 关键词：Bronchiale glandul?re Papillome ; Papill?re Adenokarzinome ; Bronchustumor ; Molekularbiologie ; Mutation ; Bronchial glandular papilloma ; Papillar adenocarcinoma ; Bronchial tumor ; Molecular biology ; Mutation
• 刊名：Der Pathologe
• 出版年：2013
• 出版时间：July 2013
• 年：2013
• 卷：34
• 期：4
• 页码：338-342
• 全文大小：672KB
• 参考文献：1. Basheda S, Gephardt GN, Stoller JK (1991) Columnar papilloma of the bronchus. Case report and literature review. Am Rev Respir Dis 144:1400-402 CrossRef
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  13. Niklinski J, Niklinska W, Chyczewski L et al (2001) Molecular genetic abnormalities in premalignant lung lesions: biological and clinical implications. Eur J Cancer Prev 10:213-26 CrossRef
  
• 作者单位：PD Dr. med. J. Wohlschl?ger (1)
  S. Welter MD (2)
  G. Stamatis MD (2)
  D. Theegarten MD (1)
  T. Hager MD (1)
  F. Mairinger MD (1)
  K. Worm MD (1)
  K.W. Schmid MD (1)
  K.M. Müller MD (3)
  
  1. Institut für Pathologie und Neuropathologie, Universit?tsklinik Essen, Universit?t Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Deutschland
  2. Abteilung für Thoraxchirurgie und thorakale Endoskopie, Ruhrlandklinik Essen, Westdeutsches Tumorzentrum, Universit?tsklinik Essen, Universit?t Duisburg-Essen, Essen, Deutschland
  3. Gerhard-Domagk-Institut für Pathologie, Universit?tsklinik Münster, Westf?lische Wilhelms-Universit?t, Münster, Deutschland
  

文摘

Benign epithelial tumors of the tracheobronchial system and the lungs are exceedingly rare. These entities encompass squamous and glandular papillomas (as well as their mixed forms) and adenomas (alveolar adenoma, papillary adenoma, salivary gland-like pleomorphic and mucinous adenomas and mucinous cystadenomas). These tumors are considered to be biologically benign neoplasms; however, they can pose considerable diagnostic difficulties, especially during frozen section evaluation, as they can mimic malignant tumors and in particular they can resemble well differentiated papillary adenocarcinomas. As a result of the extreme rarity of these tumors only a few descriptive diagnostic series exist and a systematic investigation including molecular data does not exist. This article presents the case of a 64-year-old patient with a glandular papilloma of the right main bronchus including the immunohistochemical and molecular work-up as well as a review of the current literature.