Simple and Fast Voltammetric Method for Assaying Monacolin K in Red Yeast Rice Formulated Products
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- 作者：Biljana Nigovi? ; Mario Zavr?ki ; Miranda Serti? ; Ana Mornar
- 关键词：Monacolin K ; Lovastatin ; Voltammetry ; Red yeast rice ; Cholesterol ; lowering dietary supplements
- 刊名：Food Analytical Methods
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：8
- 期：1
- 页码：180-188
- 全文大小：390 KB
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19. Nigovi? B, Pavkovi? I (2009) Preconcentration - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Food Science
Chemistry
Microbiology
Analytical Chemistry - 出版者：Springer New York
- ISSN：1936-976X
文摘
The red yeast rice formulated products, used worldwide as cholesterol-lowering dietary supplements, have the main active ingredient monacolin K which is actually lovastatin registered as the first statin drug. In this work, a rapid and simple square-wave voltammetric method was developed for determination of monacolin K based on the electrochemical reduction of the carbonyl group in lactone ring. Considering the pH dependence of current response and the interconversion of monacolin K to its acid form, the Britton-Robinson buffer of pH?5.0 was selected as a supporting electrolyte for analytical measurements. The net square-wave voltammetric response of monacolin K was shifted towards more negative potential values by increasing the concentration of analytes. The peak current was linearly proportional to monacolin K concentration in the range of 0.25-0?μg/mL. The fully validated method was successfully applied for fast screening and direct voltammetric determination of monacolin K in red yeast rice products formulated in various dosage forms. To evaluate the proposed voltammetric method, the results obtained were compared with those obtained by HPLC methods.