Chronic treatment with the selective NOP receptor antagonist [Nphe¹,Arg¹⁴,Lys¹⁵]N/OFQ-NH₂ (UFP-101) reverses the behavioural and biochemical effects of unpredictable chronic mild stress in rats

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• 作者：Giovanni Vitale ; Valentina Ruggieri ; Monica Filaferro ; Claudio Frigeri ; Silvia Alboni ; Fabio Tascedda ; Nicoletta Brunello ; Remo Guerrini ; Carlo Cifani and Maurizio Massi
• 关键词：UFP ; 101 ; Depression ; Chronic mild stress ; Corticosterone ; Serotonin ; Rat
• 刊名：Psychopharmacology
• 出版年：2009
• 出版时间：December, 2009
• 年：2009
• 卷：207
• 期：2
• 页码：173-189
• 全文大小：380.0 KB

文摘

Introduction The present study was designed to assess the antidepressant effects of UFP-101, a selective nociceptin/orphanin FQ peptide (NOP) receptor antagonist, in a validated animal model of depression: the chronic mild stress (CMS).