Usefulness of pneumococcal antigen detection in pleural effusion for the rapid diagnosis of infection by Streptococcus pneumoniae

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• 作者：Juan Casado Flores (1)
  Montserrat Nieto Moro (1)
  Sonsoles Berrón (2)
  Raquel Jiménez (1)
  Julio Casal (2)
  
• 关键词：Pleural effusion ; Children ; S. pneumoniae ; Immunochromatographic test
• 刊名：European Journal of Pediatrics
• 出版年：2010
• 出版时间：May 2010
• 年：2010
• 卷：169
• 期：5
• 页码：581-584
• 全文大小：98KB
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• 作者单位：Juan Casado Flores (1)
  Montserrat Nieto Moro (1)
  Sonsoles Berrón (2)
  Raquel Jiménez (1)
  Julio Casal (2)
  
  1. Pediatric Critical Care Unit, Hospital Infantil Universitario Ni?o Jesús, Madrid, Spain
  2. Spanish National Reference Pneumococcal Laboratory, Institute of Health Carlos III, Majadahonda, Madrid, Spain
  

文摘

Pleural effusion is increasingly reported in children. Standard culture of blood or pleural fluid is frequently negative and molecular diagnosis by polymerase chain reaction is not available in all hospitals. The Binax NOW Streptococcus pneumoniae Antigen test (Binax, Portland, USA) is a rapid immunochromatographic test (ICT) for the detection of the C polysaccharide antigen. We evaluated the Binax NOW test on the pleural fluid of 73 children hospitalized with pleural effusion over a period of 4?years. In our sample, the sensitivity and specificity of ICT were high (88% and 71%, respectively), with a positive predictive value of 96%. Detection of the pneumococcal antigen in pleural fluid by ICT is easy and quick, and enables us to identify the pneumococcal origin of the effusion, thus, making the treatment of complicated pneumonia suitably and early.