Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris
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- 作者：Kyung Mook Choi (1)
Soon Young Hwang (2)
Ho Chel Hong (1)
Hae Yoon Choi (1)
Hye Jin Yoo (1)
Byung-Soo Youn (3)
Sei Hyun Baik (1)
Hong Seog Seo (4) - 关键词：C1q/tumor necrosis factor ; related protein ; 3 ; Progranulin ; Coronary artery disease ; Acute coronary syndrome ; Stable angina pectoris ; Adipokines
- 刊名：Cardiovascular Diabetology
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：13
- 期：1
- 全文大小：220 KB
- 作者单位：Kyung Mook Choi (1)
Soon Young Hwang (2)
Ho Chel Hong (1)
Hae Yoon Choi (1)
Hye Jin Yoo (1)
Byung-Soo Youn (3)
Sei Hyun Baik (1)
Hong Seog Seo (4)
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
2. Department of Biostatistics, College of Medicine, Korea University, Seoul, Korea
3. AdipoGen, Inc, Venture Building B, Songdo Technopark, 7-50 Songdo-dong, Yeonsu-gu, Incheon, Korea
4. Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 80 Guro-Dong, Guro-Gu, Seoul, 152-050, Korea - ISSN：1475-2840
文摘
Background C1q/TNF-related protein-3 (CTRP-3), an adiponectin paralog, and progranulin were recently identified as novel adipokines which may link obesity with glucose dysregulation and subclinical inflammation. We analyzed the relationship between CTRP-3, progranulin and coronary artery disease (CAD) in Korean men and women. Methods Circulating CTRP-3 and progranulin levels were examined in 362 Korean adults with acute coronary syndrome (ACS, n--9), stable angina pectoris (SAP, n--5), and control subjects (n--08) along with various kinds of cardiometabolic risk factors. Results CTRP-3 concentrations were significantly decreased in patients with ACS or SAP compared to control subjects (P <0.001, respectively), whereas progranulin and adiponectin levels were similar. Correlation analysis adjusted for age and gender exhibited that CTRP-3 levels showed significant negative relationship with glucose (r--0.110, P--.041) and high sensitive C-reactive protein (hsCRP) levels (r--0.159, P--.005), and positive relationship with HDL-cholesterol (r--.122, P--.025) and adiponectin levels (r--.194, P <0.001). In a multivariate logistic regression analysis, the odds ratio for CAD risk was 5.14 (95% CI, 1.83-14.42) in the second, and 9.04 (95% CI, 2.81-29.14) in the first tertile of CTRP-3 levels compared to third tertile after adjusting for other cardiometabolic risk variables. Conclusions Patients with ACS or SAP had significantly lower circulating CTRP-3 concentrations compared to control subjects, although progranulin levels were not different. These results suggest the possibility that CTRP-3 might be useful for assessing the risk of CAD. Trial registration (Clinical trials No.: NCT01594710)