Elastofibroma dorsi: a case report with an immunohistochemical and ultrastructural studies

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• 作者：Natsuko Kakudo ; Naoki Morimoto ; Takeshi Ogawa…
• 关键词：Elastofibroma dorsi ; CD34 ; Vimentin ; α ; Smooth muscle actin ; Microfibrils ; Elastin
• 刊名：Medical Molecular Morphology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：49
• 期：1
• 页码：42-47
• 全文大小：3,213 KB
• 参考文献：1.Jarvi O, Saxen E (1961) Elastofibroma dorse. Acta Pathol et Microbiol Scand Suppl 51(Suppl 144):83–84
  2.Go PH, Meadows MC, Deleon EM, Chamberlain RS (2010) Elastofibroma dorsi: a soft tissue masquerade. Int J Shoulder Surg 4:97–101CrossRef PubMed PubMedCentral
  3.Braham E, Hergli I, Boudaya MS, Ismail O, Ayadi-Kaddour A, Kilani T, El Mezni F (2013) Elastofibroma of scapula: a case report and literature review. Ann Transl Med 1:31PubMed PubMedCentral
  4.Aigelsreiter A, Pichler M, Pixner T, Janig E, Schuller M, Lackner C, Scheipl S, Beham A, Regauer S (2013) Clusterin expression in elastofibroma dorsi. Histol Histopathol 28:597–603PubMed
  5.Nishio J, Isayama T, Iwasaki H, Naito M (2012) Elastofibroma dorsi: diagnostic and therapeutic algorithm. J Shoulder Elbow Surg Am Shoulder Elbow Surg 21:77–81CrossRef
  6.Oueslati S, Douira-Khomsi W, Bouaziz MC, Zaouia K (2006) Elastofibroma dorsi: a report on 6 cases. Acta Orthop Belg 72:237–242PubMed
  7.Kastner M, Salai M, Fichman S, Heller S, Dudkiewicz I (2009) Elastofibroma at the scapular region. Isr Med Assoc J 11:170–172PubMed
  8.Akhtar M, Miller RM (1977) Ultrastructure of elastofibroma. Cancer 40:728–735CrossRef PubMed
  9.Kuroda N, Hamaguchi N, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH (2008) Elastofibroma: a histochemical, immunohistochemical, and ultrastructural study of two patients. Med Mol Morphol 41:179–182CrossRef PubMed
  10.Yamazaki K (2007) An ultrastructural and immunohistochemical study of elastofibroma: CD 34, MEF-2, prominin 2 (CD133), and factor XIIIa-positive proliferating fibroblastic stromal cells connected by Cx43-type gap junctions. Ultrastruct Pathol 31:209–219CrossRef PubMed
  11.Kayaselcuk F, Demirhan B, Kayaselcuk U, Ozerdem OR, Tuncer I (2002) Vimentin, smooth muscle actin, desmin, S-100 protein, p53, and estrogen receptor expression in elastofibroma and nodular fasciitis. Ann Diagn Pathol 6:94–99CrossRef PubMed
  12.Rosenbloom J, Abrams WR, Mecham R (1993) Extracellular matrix 4: the elastic fiber. FASEB J Off Publ Fed Am Soc Exp Biol 7:1208–1218
  13.Kielty CM, Sherratt MJ, Shuttleworth CA (2002) Elastic fibres. J Cell Sci 115:2817–2828PubMed
  14.Ramirez F, Sakai LY, Dietz HC, Rifkin DB (2004) Fibrillin microfibrils: multipurpose extracellular networks in organismal physiology. Physiol Genomics 19:151–154CrossRef PubMed
  15.Dixon AY, Lee SH (1980) An ultrastructural study of elastofibromas. Hum Pathol 11:257–262CrossRef PubMed
  
• 作者单位：Natsuko Kakudo (1)
  Naoki Morimoto (1)
  Takeshi Ogawa (1)
  Masakatsu Hihara (1)
  Rina Koseki (1)
  Kenji Kusumoto (1)
  
  1. Department of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Medical Microbiology
  Pathology
  Biological Microscopy
  Molecular Medicine
  
• 出版者：Springer Japan
• ISSN：1860-1499

文摘

Elastofibroma is a rare, benign, fibrous tumor formed by the proliferation of characteristic elastic fibers that commonly occurs between the lower margin of the scapula and the ribcage. We undertook a histochemical, immunohistochemical, and ultrastructural study of an elastofibroma dorsi beneath the right scapula of a 77-year-old woman. Tumor cells comprised collagen fiber bundles, numerous elastic fibers, and spindle cells resembling fibroblasts. The elastic and collagen fibers in the tumor were stained positively with Elastic van Gieson and Masson trichrome staining, respectively. Immunostaining showed that the fibroblasts were strongly positive for CD34, positive for vimentin, and weakly positive for α-smooth muscle actin. Ultrastructural observations revealed elastin and microfibrils between numerous irregularly arranged collagen fiber bundles. Signs suggestive of elastin deposition were also evident in the tangled collagen fibers themselves. The fibroblasts contained a large amount of rough endoplasmic reticulum and were surrounded on the outside of cells by microfibrils and collagen fibers. Although fibroblasts may produce large quantities of elastin, microfibrils, and collagen, our findings suggested that the deposition of elastin on collagen fibers may be involved in the formation of abnormal elastic fibers.