Difference in autologous blood transfusion-induced inflammatory responses between acute normovolemic hemodilution and preoperative donation
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- 作者：Yoshifumi Kotake ; Michiko Yamamoto ; Midori Matsumoto ; Takashige Yamada ; Hiromasa Nagata ; Hiroshi Morisaki and Junzo Takeda
- 关键词：Preoperative donation ; Acute normovolemic hemodilution ; Neutrophil elastase ; Interleukin ; HES 70/0.5
- 刊名：Journal of Anesthesia
- 出版年：2009
- 出版时间：February, 2009
- 年：2009
- 卷：23
- 期：1
- 页码：61-66
- 全文大小：159.6 KB
文摘
Purpose The inflammatory response triggered by transfusion is implicated in the pathophysiology of transfusion-related immunomodulation. The authors hypothesized that two distinctive autotransfusion methods, acute normovolemic hemodilution (ANH) and preoperative donation (PD), have different influences on both inflammatory mediator generation during storage and the inflammatory response after a transfusion. The purpose of this study was to compare the plasma concentrations of neutrophil elastase (NE), interleukin (IL)-6, IL-8, and IL-10 in patients who underwent either of these two autologous transfusion methods.