Effects of magnesium sulfate on neuromuscular function and spontaneous breathing during sevoflurane and spinal anesthesia

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• 作者：Ryohei Serita ; Hiroshi Morisaki ; Chikako Tanaka ; Shizuko Kosugi ; Shigeki Sakuraba and Junzo Takeda
• 关键词：Magnesium sulfate ; Neuromuscular function ; Respiratory function ; Sevoflurane
• 刊名：Journal of Anesthesia
• 出版年：2007
• 出版时间：February, 2007
• 年：2007
• 卷：21
• 期：1
• 页码：86-89
• 全文大小：234 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Anesthesiology
  
• 出版者：Springer Japan
• ISSN：1438-8359

文摘

The purpose of the present study was to determine the effects of magnesium sulfate (MgSO4) on the neuromuscular function and spontaneous breathing of patients under sevoflurane and spinal anesthesia. Twenty-two patients with a history of arrhythmia undergoing elective knee surgery were randomly assigned to two groups: group M (n = 11), administered with MgSO4 40?mg·kg?1, and group S (n = 11), administered with saline. A combination of spinal anesthesia with 2% sevoflurane inhalation was applied to all patients under spontaneous breathing. Tidal volume (Vt), respiratory rate (RR) and end-tidal carbon dioxide (ETCO 2) were measured before the MgSO4 or saline injection and measurements were repeated at 5, 15, 30, and 45 min after the injection. Neuromuscular function was continuously monitored with an acceleromyograph to record the acceleration of the adductor pollicis by stimulating the ulnar nerve at a frequency of 0.1?Hz. The Vt, RR, and ETCO 2 showed little change in either group, and there was no significant difference between, the groups. The single-twitch response showed significant differences between the two groups (P = 0.0006). The present study indicated that the MgSO4 had a minimal effect on spontaneous breathing in patients undergoing sevoflurane and spinal anaesthesia, but that it attenuated the safety margin of neuromuscular function.