Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh

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• 作者：Akio Yamasaki ; Chizu Kameda ; Rui Xu ; Haruo Tanaka ; Takehiko Tasaka ; Nobuhito Chikazawa ; Hiroyuki Suzuki ; Takashi Morisaki ; Makoto Kubo and Hideya Onishi ; et al.
• 关键词：NF ; κ ; B ; Hh pathway ; Monocytes ; Pancreatic cancer
• 刊名：Cancer Immunology, Immunotherapy
• 出版年：2010
• 出版时间：May, 2010
• 年：2010
• 卷：59
• 期：5
• 页码：675-686
• 全文大小：599.8 KB

文摘

Recently, it was reported that Hh signaling is activated in tumor stromal cells but not in tumor cells themselves and that stromal cells may play a role in the proliferation of cancer cells. This suggests the possibility that stromal cells have an important role in the proliferation of tumor cells that may be mediated through Hh signaling. In this report, we present for the first time that inflammation-stimulated monocytes produce Shh through activation of the NF-κB signaling pathway, and that the Shh produced promotes the proliferation of pancreatic cancer cells in a paracrine manner through Hh signaling.